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10.1038/pr.2016.58

http://scihub22266oqcxt.onion/10.1038/pr.2016.58
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C4929034!4929034!27002984
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suck abstract from ncbi


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pmid27002984      Pediatr+Res 2016 ; 80 (1): 28-34
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  • Clinical Associations with Immature Breathing in Preterm Infants: Part 2: Periodic Breathing #MMPMID27002984
  • Patel M; Mohr M; Lake D; Delos J; Moorman JR; Sinkin RA; Kattwinkel J; Fairchild K
  • Pediatr Res 2016[Jul]; 80 (1): 28-34 PMID27002984show ga
  • Background: Periodic breathing (PB) is a normal immature breathing pattern in neonates that, if extreme, may be associated with pathologic conditions. Methods: We used our automated PB detection system to analyze all bedside monitor chest impedance data on all infants <35 weeks? gestation in the University of Virginia Neonatal Intensive Care Unit from 2009-2014 (n=1211). Percent time spent in PB was calculated hourly (>50 infant-years? data). Extreme PB was identified as a 12h period with PB >6 standard deviations above the mean for gestational age (GA) and post-menstrual age (PMA) and >10% time in PB. Results: PB increased with GA, with the highest amount in infants 30-33 weeks? GA at about 2 weeks? chronologic age. Extreme PB was identified in 76 infants and in 45% was temporally associated with clinical events including infection or necrotizing enterocolitis (NEC), immunizations, or caffeine discontinuation. In 8/28 cases of septicemia and 10/21 cases of NEC there was a >2-fold increase in %PB over baseline in the day prior to diagnosis. Conclusion: Infants <35 weeks GA spend, on average, <6% of the time in PB. An acute increase in PB may reflect illness or physiological stressors or may occur without any apparent clinical event.
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