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10.1002/eji.201546050 http://scihub22266oqcxt.onion/10.1002/eji.201546050 C4928683!4928683!26990433     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (6): 1504-10 Nephropedia Template TP {{tp|p=26990433|t=2016. STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells |pdf=|usr=}}{{26990433}} gab.com Text STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26990433 #FOAvip Type I Interferon (IFN-?/?) plays a critical role in suppressing viral replication by driving the transcription of hundreds of interferon sensitive genes (ISGs). While many ISGs are transcriptionally activated by the ISGF3 complex, the significance of other signaling intermediates in IFN-?/?-mediated gene regulation remains elusive, particularly in rare cases of gene silencing. In human Th2 cells, IFN-?/? signaling suppressed IL5 and IL13 mRNA expression during recall responses to T cell receptor (TCR) activation. This suppression occurred through a rapid reduction in the rate of nascent transcription, independent of de novo expression of ISGs. Further, IFN-?/?-mediated STAT4 activation was required for repressing the human IL5 gene, and disrupting STAT4 dimerization reversed this effect. This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-?/? signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells. Twit Text FOAVip STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26990433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26990433 #FOAvip English Wikipedia <ref>{{Cite pmid|26990433}}</ref> STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells #MMPMID26990433 Gonzales-van Horn SR; Estrada LD; van Oers NSC; Farrar JD Eur J Immunol 2016[Jun]; 46 (6): 1504-10 PMID26990433show ga Type I Interferon (IFN-?/?) plays a critical role in suppressing viral replication by driving the transcription of hundreds of interferon sensitive genes (ISGs). While many ISGs are transcriptionally activated by the ISGF3 complex, the significance of other signaling intermediates in IFN-?/?-mediated gene regulation remains elusive, particularly in rare cases of gene silencing. In human Th2 cells, IFN-?/? signaling suppressed IL5 and IL13 mRNA expression during recall responses to T cell receptor (TCR) activation. This suppression occurred through a rapid reduction in the rate of nascent transcription, independent of de novo expression of ISGs. Further, IFN-?/?-mediated STAT4 activation was required for repressing the human IL5 gene, and disrupting STAT4 dimerization reversed this effect. This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-?/? signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells. äSTAT4-mediated transcriptional repression of the IL5 gene in human mem(epmc).pdf DeepDyve Pubget Overpricing