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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Infect+Dis
2016 ; 63
(2
): 186-94
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English Wikipedia
Inpatient Mortality Among Solid Organ Transplant Recipients Hospitalized for
Sepsis and Severe Sepsis
#MMPMID27217215
Donnelly JP
; Locke JE
; MacLennan PA
; McGwin G Jr
; Mannon RB
; Safford MM
; Baddley JW
; Muntner P
; Wang HE
Clin Infect Dis
2016[Jul]; 63
(2
): 186-94
PMID27217215
show ga
BACKGROUND: Solid organ transplant (SOT) recipients are at elevated risk of
sepsis. The impact of SOT on outcomes following sepsis is unclear. METHODS: We
performed a retrospective cohort study using data from University HealthSystem
Consortium, a consortium of academic medical center affiliates. We examined the
association between SOT and mortality among patients hospitalized with severe
sepsis or explicitly coded sepsis in 2012-2014. We used International
Classification of Diseases, Ninth Revision (ICD-9) codes to identify severe
sepsis, explicitly coded sepsis, and SOT (kidney, liver, heart, lung, pancreas,
or intestine transplants). We fit random-intercept logistic regression models to
account for clustering by hospital. RESULTS: There were 903 816 severe sepsis
hospitalizations (39 618 [4.4%] with SOT) and 410 623 sepsis hospitalizations (14
526 [3.9%] with SOT) in 250 hospitals. SOT recipients were younger and more
likely to be insured by Medicare than those without SOT. Among hospitalizations
for severe sepsis and sepsis, in-hospital mortality was lower among those with vs
those without SOT (5.5% vs 9.4% for severe sepsis; 8.7% vs 12.7% for sepsis).
After adjustment, the odds ratio for mortality comparing SOT patients vs non-SOT
was 0.83 (95% confidence interval [CI], .79-.87) for severe sepsis and 0.78 (95%
CI, .73-.84) for sepsis. Compared to non-SOT patients, kidney, liver, and
co-transplant (kidney-pancreas/kidney-liver) recipients demonstrated lower
mortality. No association was present for heart transplant, and lung transplant
was associated with higher mortality. CONCLUSIONS: Among patients hospitalized
for severe sepsis or sepsis, those with SOT had lower inpatient mortality than
those without SOT. Identifying the specific strategies employed for populations
with improved mortality could inform best practices for sepsis among SOT and
non-SOT populations.