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Marine pharmacology in 2001--2002: marine compounds with anthelmintic,
antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory,
antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral
activities; affecting the cardiovascular, immune and nervous systems and other
miscellaneous mechanisms of action
#MMPMID15919242
Mayer AM
; Hamann MT
Comp Biochem Physiol C Toxicol Pharmacol
2005[Mar]; 140
(3-4
): 265-86
PMID15919242
show ga
During 2001--2002, research on the pharmacology of marine chemicals continued to
be global in nature involving investigators from Argentina, Australia, Brazil,
Canada, China, Denmark, France, Germany, India, Indonesia, Israel, Italy, Japan,
Mexico, Netherlands, New Zealand, Pakistan, the Philippines, Russia, Singapore,
Slovenia, South Africa, South Korea, Spain, Sweden, Switzerland, Thailand, United
Kingdom, and the United States. This current article, a sequel to the authors'
1998, 1999 and 2000 marine pharmacology reviews, classifies 106 marine chemicals
derived from a diverse group of marine animals, algae, fungi and bacteria, on the
basis of peer-reviewed preclinical pharmacology. Anthelmintic, antibacterial,
anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal,
antituberculosis or antiviral activities were reported for 56 marine chemicals.
An additional 19 marine compounds were shown to have significant effects on the
cardiovascular, immune and nervous system as well as to possess anti-inflammatory
and antidiabetic effects. Finally, 31 marine compounds were reported to act on a
variety of molecular targets and thus may potentially contribute to several
pharmacological classes. Thus, during 2001--2002 pharmacological research with
marine chemicals continued to contribute potentially novel chemical leads for the
ongoing global search for therapeutic agents for the treatment of multiple
disease categories.