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10.3233/JPD-150700 http://scihub22266oqcxt.onion/10.3233/JPD-150700 C4927927!4927927 !26889632     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26889632 &cmd=llinks): Failed to open stream: HTTP request failed! 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Safinamide as Add-On Therapy to Levodopa in Mid- to Late-Stage Parkinson s Disease Fluctuating Patients: Post hoc Analyses of Studies 016 and SETTLE |pdf=|usr=}}{{26889632 }} gab.com Text Safinamide as Add-On Therapy to Levodopa in Mid- to Late-Stage Parkinson s Disease Fluctuating Patients: Post hoc Analyses of Studies 016 and SETTLE JO: J Parkinsons Dis http://www.kidney.de/pget.php?&tw=1&pmid=26889632 #FOAvip BACKGROUND: Studies 016 and SETTLE showed that safinamide was safe and effective as adjunct therapy in patients with advanced Parkinson's disease (PD) and motor fluctuations. The addition of safinamide to a stable dose of levodopa alone or with other antiparkinsonian medications significantly increased ON time with no/non-troublesome dyskinesia, decreased OFF time and improved Parkinson's symptoms. OBJECTIVE: To evaluate the clinical effects of safinamide 100 mg/day on motor fluctuations and cardinal Parkinson's symptoms in specific patient subgroups using pooled data from Studies 016 and SETTLE. METHODS: Both studies were double blind, placebo-controlled, randomized, phase 3 trials which enrolled patients with mid- to late-stage PD experiencing motor fluctuations while receiving optimized and stable doses of levodopa, alone or with other dopaminergic treatments. The present post-hoc analyses assessed the change from baseline in ON time (with no or non-troublesome dyskinesia) and OFF time in subgroups of patients who were receiving only levodopa at baseline, who were classified as "mild fluctuators" (daily OFF time ?4 h), and who were receiving concomitant dopaminergic therapy, with or without amantadine, and the effects of safinamide versus placebo on individual cardinal PD symptoms during ON time. RESULTS: Safinamide significantly increased mean ON time (with no or non-troublesome dyskinesia) and reduced mean OFF time when used as first adjunct therapy in levodopa-treated patients and patients with mild motor fluctuations. Mean daily ON time (with no or non-troublesome dyskinesia) and OFF time were favorably changed, compared with placebo, to similar extents regardless of whether patients were receiving concomitant dopamine agonists, catechol-O-methyltransferase inhibitors and amantadine. Additionally, safinamide improved bradykinesia, rigidity, tremor and gait. CONCLUSIONS: Safinamide was a safe and effective first adjunct therapy in levodopa-treated patients and improved 4/5 cardinal symptoms of PD while providing benefits to mild and non-mild fluctuators and patients receiving other concomitant dopaminergic therapies. Twit Text FOAVip Safinamide as Add-On Therapy to Levodopa in Mid- to Late-Stage Parkinson s Disease Fluctuating Patients: Post hoc Analyses of Studies 016 and SETTLE ????J Parkinsons Dis http://www.kidney.de/pget.php?&tw=1&pmid=26889632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26889632 #FOAvip English Wikipedia <ref>{{Cite pmid|26889632 }}</ref> Safinamide as Add-On Therapy to Levodopa in Mid- to Late-Stage Parkinson s Disease Fluctuating Patients: Post hoc Analyses of Studies 016 and SETTLE #MMPMID26889632 Cattaneo C ; Sardina M ; Bonizzoni E J Parkinsons Dis 2016[]; 6 (1 ): 165-73 PMID26889632 show ga BACKGROUND: Studies 016 and SETTLE showed that safinamide was safe and effective as adjunct therapy in patients with advanced Parkinson's disease (PD) and motor fluctuations. The addition of safinamide to a stable dose of levodopa alone or with other antiparkinsonian medications significantly increased ON time with no/non-troublesome dyskinesia, decreased OFF time and improved Parkinson's symptoms. OBJECTIVE: To evaluate the clinical effects of safinamide 100 mg/day on motor fluctuations and cardinal Parkinson's symptoms in specific patient subgroups using pooled data from Studies 016 and SETTLE. METHODS: Both studies were double blind, placebo-controlled, randomized, phase 3 trials which enrolled patients with mid- to late-stage PD experiencing motor fluctuations while receiving optimized and stable doses of levodopa, alone or with other dopaminergic treatments. The present post-hoc analyses assessed the change from baseline in ON time (with no or non-troublesome dyskinesia) and OFF time in subgroups of patients who were receiving only levodopa at baseline, who were classified as "mild fluctuators" (daily OFF time ?4 h), and who were receiving concomitant dopaminergic therapy, with or without amantadine, and the effects of safinamide versus placebo on individual cardinal PD symptoms during ON time. RESULTS: Safinamide significantly increased mean ON time (with no or non-troublesome dyskinesia) and reduced mean OFF time when used as first adjunct therapy in levodopa-treated patients and patients with mild motor fluctuations. Mean daily ON time (with no or non-troublesome dyskinesia) and OFF time were favorably changed, compared with placebo, to similar extents regardless of whether patients were receiving concomitant dopamine agonists, catechol-O-methyltransferase inhibitors and amantadine. Additionally, safinamide improved bradykinesia, rigidity, tremor and gait. CONCLUSIONS: Safinamide was a safe and effective first adjunct therapy in levodopa-treated patients and improved 4/5 cardinal symptoms of PD while providing benefits to mild and non-mild fluctuators and patients receiving other concomitant dopaminergic therapies. |Aged [MESH] |Alanine/administration & dosage/*analogs & derivatives [MESH] |Antiparkinson Agents/*administration & dosage [MESH] |Benzylamines/*administration & dosage [MESH] |Double-Blind Method [MESH] |Drug Therapy, Combination [MESH] |Female [MESH] |Humans [MESH] |Levodopa/*administration & dosage [MESH] |Male [MESH] |Middle Aged [MESH] |Parkinson Disease/*drug therapy [MESH]Safinamide as Add-On Therapy to Levodopa in Mid- to Late-Stage Parkins(epmc).pdf DeepDyve Pubget Overpricing