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2016 ; 47
(7
): 1933-5
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English Wikipedia
Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective
Intra-Arterial Cold Saline Infusion
#MMPMID27197848
Chen J
; Liu L
; Zhang H
; Geng X
; Jiao L
; Li G
; Coutinho JM
; Ding Y
; Liebeskind DS
; Ji X
Stroke
2016[Jul]; 47
(7
): 1933-5
PMID27197848
show ga
BACKGROUND AND PURPOSE: We conducted a pilot feasibility and safety study of
selective brain cooling with intra-arterial infusion of cold saline combined with
endovascular reperfusion for acute ischemic stroke. METHODS: Patients with
large-vessel occlusion within 8 hours after symptom onset were enrolled. All
patients received intra-arterial recanalization combined with infusion of cold
isotonic saline (4°C) in the ischemic territory through the angiographic
catheter. RESULTS: Twenty-six patients underwent the procedure, which was
technically successful in all. The temperature of ischemic cerebral tissue was
decreased by at least 2°C during infusion of the cold solution, and systemic
temperature was mildly reduced (maximum 0.3°C). No obvious complications related
to intra-arterial hypothermia were observed. CONCLUSIONS: Selective brain cooling
by intra-arterial infusion of cold saline combined with endovascular
recanalization therapy in acute ischemic stroke seems feasible and safe.
|*Endovascular Procedures
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Brain Ischemia/drug therapy/*therapy
[MESH]
|Cold Temperature
[MESH]
|Combined Modality Therapy
[MESH]
|Feasibility Studies
[MESH]
|Female
[MESH]
|Fibrinolytic Agents/administration & dosage/therapeutic use
[MESH]
|Humans
[MESH]
|Hypothermia, Induced/*methods
[MESH]
|Infusions, Intra-Arterial
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Pilot Projects
[MESH]
|Sodium Chloride/administration & dosage/*therapeutic use
[MESH]