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10.1091/mbc.E16-04-0264 http://scihub22266oqcxt.onion/10.1091/mbc.E16-04-0264 C4927284!4927284 !27170174     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27170174 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2016 ; 27 (13 ): 2119-32 Nephropedia Template TP {{tp|p=27170174 |t=2016. A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes |pdf=|usr=}}{{27170174 }} gab.com Text A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27170174 #FOAvip Numerous proteins act in concert to sculpt membrane compartments for cell signaling and metabolism. These proteins may act as curvature sensors, membrane benders, and scaffolding molecules. Here we show that endophilin, a critical protein for rapid endocytosis, quickly transforms from a curvature sensor into an active bender upon membrane association. We find that local membrane deformation does not occur until endophilin inserts its amphipathic helices into lipid bilayers, supporting an active bending mechanism through wedging. Our time-course studies show that endophilin continues to drive membrane changes on a seconds-to-minutes time scale, indicating that the duration of endocytosis events constrains the mode of endophilin action. Finally, we find a requirement of coordinated activities between wedging and scaffolding for endophilin to produce stable membrane tubules in vitro and to promote synaptic activity in vivo. Together these data demonstrate that endophilin is a multifaceted molecule that precisely integrates activities of sensing, bending, and stabilizing curvature to sculpt membranes with speed. Twit Text FOAVip A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27170174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27170174 #FOAvip English Wikipedia <ref>{{Cite pmid|27170174 }}</ref> A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes #MMPMID27170174 Poudel KR ; Dong Y ; Yu H ; Su A ; Ho T ; Liu Y ; Schulten K ; Bai J Mol Biol Cell 2016[Jul]; 27 (13 ): 2119-32 PMID27170174 show ga Numerous proteins act in concert to sculpt membrane compartments for cell signaling and metabolism. These proteins may act as curvature sensors, membrane benders, and scaffolding molecules. Here we show that endophilin, a critical protein for rapid endocytosis, quickly transforms from a curvature sensor into an active bender upon membrane association. We find that local membrane deformation does not occur until endophilin inserts its amphipathic helices into lipid bilayers, supporting an active bending mechanism through wedging. Our time-course studies show that endophilin continues to drive membrane changes on a seconds-to-minutes time scale, indicating that the duration of endocytosis events constrains the mode of endophilin action. Finally, we find a requirement of coordinated activities between wedging and scaffolding for endophilin to produce stable membrane tubules in vitro and to promote synaptic activity in vivo. Together these data demonstrate that endophilin is a multifaceted molecule that precisely integrates activities of sensing, bending, and stabilizing curvature to sculpt membranes with speed. |Adaptor Proteins, Signal Transducing/*genetics/*metabolism/physiology [MESH] |Animals [MESH] |Cell Membrane/metabolism [MESH] |Endocytosis/genetics/physiology [MESH] |Lipid Bilayers/metabolism [MESH] |Membranes/metabolism [MESH] |Mice [MESH] |Models, Molecular [MESH] |Protein Structure, Secondary [MESH] |Protein Structure, Tertiary [MESH]A time course of orchestrated endophilin action in sensing, bending, a(epmc).pdf DeepDyve Pubget Overpricing