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10.1681/ASN.2015050478 http://scihub22266oqcxt.onion/10.1681/ASN.2015050478 C4926975!4926975 !26614383     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26614383 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2016 ; 27 (7 ): 2188-95 Nephropedia Template TP {{tp|p=26614383 |t=2016. Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies |pdf=|usr=}}{{26614383 }} gab.com Text Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26614383 #FOAvip The presence of tubuloreticular inclusions (TRIs) in native glomerular endothelial cells associates with viral infections and lupus nephritis. However, the associations of TRIs in renal transplant biopsy specimens are not known. We analyzed data from 316 patients who had a transplant biopsy with electron microscopy examination; 41 of 316 (13.0%) patients had TRIs. Patients with TRIs had significantly lower allograft survival rates (50.9%) than patients without TRIs (74.3%; P=0.03). Transplant glomerulopathy-free survival was also inferior in the TRI-positive group (57.5%) compared with the TRI-negative group (87.3%; P=0.002). Serologically, hepatitis C associated with the presence of TRIs (P=0.04) along with donor-specific antibodies (P=0.01). Furthermore, patients who were TRI positive were more likely than patients who were TRI negative to have had a previous rejection episode (P=0.02). On multivariate analysis, TRIs associated with prior rejection, viral infections, and class 1 HLA donor-specific antibodies. These results show that the presence of TRIs in renal allograft biopsy specimens associates with poor allograft outcomes and serologic evidence of viral infections and alloimmunity. The association with alloimmunity is a novel finding that warrants additional investigation. Twit Text FOAVip Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26614383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26614383 #FOAvip English Wikipedia <ref>{{Cite pmid|26614383 }}</ref> Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies #MMPMID26614383 Willicombe M ; Moss J ; Moran L ; Brookes P ; Santos-Nunez E ; McLean AG ; Cairns T ; Taube D ; Cook TH ; Roufosse C J Am Soc Nephrol 2016[Jul]; 27 (7 ): 2188-95 PMID26614383 show ga The presence of tubuloreticular inclusions (TRIs) in native glomerular endothelial cells associates with viral infections and lupus nephritis. However, the associations of TRIs in renal transplant biopsy specimens are not known. We analyzed data from 316 patients who had a transplant biopsy with electron microscopy examination; 41 of 316 (13.0%) patients had TRIs. Patients with TRIs had significantly lower allograft survival rates (50.9%) than patients without TRIs (74.3%; P=0.03). Transplant glomerulopathy-free survival was also inferior in the TRI-positive group (57.5%) compared with the TRI-negative group (87.3%; P=0.002). Serologically, hepatitis C associated with the presence of TRIs (P=0.04) along with donor-specific antibodies (P=0.01). Furthermore, patients who were TRI positive were more likely than patients who were TRI negative to have had a previous rejection episode (P=0.02). On multivariate analysis, TRIs associated with prior rejection, viral infections, and class 1 HLA donor-specific antibodies. These results show that the presence of TRIs in renal allograft biopsy specimens associates with poor allograft outcomes and serologic evidence of viral infections and alloimmunity. The association with alloimmunity is a novel finding that warrants additional investigation. |*Antibodies [MESH] |*Kidney Transplantation [MESH] |Endothelial Cells [MESH] |Female [MESH] |Humans [MESH] |Kidney Glomerulus/*pathology [MESH] |Kidney/*immunology/*pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Retrospective Studies [MESH] |Tissue Donors [MESH]Tubuloreticular Inclusions in Renal Allografts Associate with Viral In(epmc).pdf DeepDyve Pubget Overpricing