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2016 ; 32
(2
): 121-6
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Antiviral Therapy in Patients with Viral Hepatitis and Hepatocellular Carcinoma:
Indications and Prognosis
#MMPMID27413730
Roderburg C
; Tacke F
; Trautwein C
Visc Med
2016[Apr]; 32
(2
): 121-6
PMID27413730
show ga
BACKGROUND: Chronic hepatitis B and C infections represent major risk factors for
the development of hepatocellular carcinoma (HCC). Recently, the management of
patients with viral hepatitis has dramatically changed. In the present review we
discuss the impact of these developments on the prevention of HCC as well as the
treatment of patients with HCC. METHODS: Studies indexed in Medline between 1990
and 2015 (November) were reviewed. The terms 'hepatocellular carcinoma', 'HCC',
'hepatitis B', 'hepatitis C', 'viral hepatitis', and combinations of these terms
were used. RESULTS: Patients with chronic hepatitis B or hepatitis C without HCC
should be evaluated for antiviral therapy, since antiviral therapy was suggested
to reduce the risk of HCC development. Cirrhotic patients infected with hepatitis
B virus (HBV) require antiviral therapy, while cirrhotics infected with hepatitis
C virus (HCV) need to be prioritized for therapy with interferon (IFN)-free
regimens. Antiviral therapy should be considered in HBV-infected patients with
HCC, especially to prevent tumor recurrence after curative-intended therapy or to
prevent hepatic decompensation. HCV-infected patients with HCC should be
considered in similar intention for IFN-free antiviral therapy, depending on the
tumor stage and life expectancy. CONCLUSION: Patients with viral hepatitis should
be considered for antiviral treatment for the prevention of HCC development as
well as during HCC treatment.