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10.1038/srep28446 http://scihub22266oqcxt.onion/10.1038/srep28446 C4926062!4926062 !27354262     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27354262 &cmd=llinks): Failed to open stream: HTTP request failed! 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Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer |pdf=|usr=}}{{27354262 }} gab.com Text Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27354262 #FOAvip We have recently demonstrated that the transcription factor MYB can modulate several cancer-associated phenotypes in pancreatic cancer. In order to understand the molecular basis of these MYB-associated changes, we conducted deep-sequencing of transcriptome of MYB-overexpressing and -silenced pancreatic cancer cells, followed by in silico pathway analysis. We identified significant modulation of 774 genes upon MYB-silencing (p?<?0.05) that were assigned to 25 gene networks by in silico analysis. Further analyses placed genes in our RNA sequencing-generated dataset to several canonical signalling pathways, such as cell-cycle control, DNA-damage and -repair responses, p53 and HIF1?. Importantly, we observed downregulation of the pancreatic adenocarcinoma signaling pathway in MYB-silenced pancreatic cancer cells exhibiting suppression of EGFR and NF-?B. Decreased expression of EGFR and RELA was validated by both qPCR and immunoblotting and they were both shown to be under direct transcriptional control of MYB. These observations were further confirmed in a converse approach wherein MYB was overexpressed ectopically in a MYB-null pancreatic cancer cell line. Our findings thus suggest that MYB potentially regulates growth and genomic stability of pancreatic cancer cells via targeting complex gene networks and signaling pathways. Further in-depth functional studies are warranted to fully understand MYB signaling in pancreatic cancer. Twit Text FOAVip Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27354262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27354262 #FOAvip English Wikipedia <ref>{{Cite pmid|27354262 }}</ref> Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer #MMPMID27354262 Azim S ; Zubair H ; Srivastava SK ; Bhardwaj A ; Zubair A ; Ahmad A ; Singh S ; Khushman M ; Singh AP Sci Rep 2016[Jun]; 6 (ä): 28446 PMID27354262 show ga We have recently demonstrated that the transcription factor MYB can modulate several cancer-associated phenotypes in pancreatic cancer. In order to understand the molecular basis of these MYB-associated changes, we conducted deep-sequencing of transcriptome of MYB-overexpressing and -silenced pancreatic cancer cells, followed by in silico pathway analysis. We identified significant modulation of 774 genes upon MYB-silencing (p? |Cell Line, Tumor [MESH] |Down-Regulation [MESH] |ErbB Receptors/genetics/metabolism [MESH] |Gene Regulatory Networks/*genetics [MESH] |Genomic Instability [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Pancreatic Neoplasms/metabolism/pathology [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-myb/antagonists & inhibitors/genetics/*metabolism [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Sequence Analysis, DNA [MESH] |Signal Transduction/*genetics [MESH] |Transcription Factor RelA/genetics/metabolism [MESH]Deep sequencing and in silico analyses identify MYB-regulated gene net(epmc).pdf DeepDyve Pubget Overpricing