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10.1111/iep.12179 http://scihub22266oqcxt.onion/10.1111/iep.12179 C4926052!4926052!27242326     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Exp+Pathol 2016 ; 97 (2): 139-49 Nephropedia Template TP {{tp|p=27242326|t=2016. Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis |pdf=|usr=}}{{27242326}} gab.com Text Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis JO: Int J Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27242326 #FOAvip Hepatic fibropoiesis has been confirmed in canine visceral leishmaniasis. In fibrotic disease, hepatic stellate cells (HSC) play an important role in fibropoiesis, undergoing activation by TGF?? to acquire characteristics of myofibroblasts. These cells show extensive capacity for proliferation, motility, contractility, collagen synthesis and extracellular matrix component synthesis. The aim of this work was to identify markers of HSC activation in 10 symptomatic and 10 asymptomatic dogs naturally infected with Leishmania (Leishmania) infantum. Eight uninfected dogs were used as controls. Alpha?actin (??SMA), vimentin and cytokeratin were investigated by immunohistochemistry as HSC markers. The cytokine TGF?? in tissue was also evaluated by immunohistochemistry. All infected dogs showed higher numbers of reticular fibres than controls. Fibropoiesis found in infected dogs was always associated with the presence of parasites and chronic granulomatous hepatitis. Positive correlation was found among fibropoiesis, parasite tissue load and expression of ??SMA. There was no correlation between fibropoiesis, vimentin and cytokeratin markers. The expression of cytokine TGF?? was higher in infected dogs than in controls, but not significantly different between symptomatic and asymptomatic dogs. These results confirm previous work describing the intense hepatic fibropoiesis in dogs naturally infected with Leishmania infantum, but now associated them with overexpression of TGF??, where ??SMA may be a superior marker for activated HSC cells in CVL. Twit Text FOAVip Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis ????Int J Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27242326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27242326 #FOAvip English Wikipedia <ref>{{Cite pmid|27242326}}</ref> Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis #MMPMID27242326 Madeira IMVM; Pereira DMO; Sousa AA; Vilela CA; Amorim IFG; Caliari MV; Souza CC; Tafuri WL Int J Exp Pathol 2016[Apr]; 97 (2): 139-49 PMID27242326show ga Hepatic fibropoiesis has been confirmed in canine visceral leishmaniasis. In fibrotic disease, hepatic stellate cells (HSC) play an important role in fibropoiesis, undergoing activation by TGF?? to acquire characteristics of myofibroblasts. These cells show extensive capacity for proliferation, motility, contractility, collagen synthesis and extracellular matrix component synthesis. The aim of this work was to identify markers of HSC activation in 10 symptomatic and 10 asymptomatic dogs naturally infected with Leishmania (Leishmania) infantum. Eight uninfected dogs were used as controls. Alpha?actin (??SMA), vimentin and cytokeratin were investigated by immunohistochemistry as HSC markers. The cytokine TGF?? in tissue was also evaluated by immunohistochemistry. All infected dogs showed higher numbers of reticular fibres than controls. Fibropoiesis found in infected dogs was always associated with the presence of parasites and chronic granulomatous hepatitis. Positive correlation was found among fibropoiesis, parasite tissue load and expression of ??SMA. There was no correlation between fibropoiesis, vimentin and cytokeratin markers. The expression of cytokine TGF?? was higher in infected dogs than in controls, but not significantly different between symptomatic and asymptomatic dogs. These results confirm previous work describing the intense hepatic fibropoiesis in dogs naturally infected with Leishmania infantum, but now associated them with overexpression of TGF??, where ??SMA may be a superior marker for activated HSC cells in CVL. äImmunohistochemical study of hepatic fibropoiesis associated with cani(epmc).pdf DeepDyve Pubget Overpricing