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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transplant
2016 ; 16
(7
): 2055-65
Nephropedia Template TP
gab.com Text
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English Wikipedia
Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing
Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression:
A Study in Rats
#MMPMID26749344
Hu X
; Okabayashi T
; Cameron AM
; Wang Y
; Hisada M
; Li J
; Raccusen LC
; Zheng Q
; Montgomery RA
; Williams GM
; Sun Z
Am J Transplant
2016[Jul]; 16
(7
): 2055-65
PMID26749344
show ga
Transplant tolerance allowing the elimination of lifelong immunosuppression has
been the goal of research for 60 years. The induction of mixed chimerism has
shown promise and has been extended successfully to large animals and to the
clinic; however, it remains cumbersome and requires heavy early
immunosuppression. In this study, we reported that four injections of AMD3100, a
CXCR4 antagonist, plus eight injections of low-dose FK506 (0.05 mg/kg per day) in
the first week after kidney transplantation extended survival, but death from
renal failure occurred at 30-90 days. Repeating the same course of AMD3100 and
FK506 at 1, 2 and 3 mo after transplant resulted in 92% allograft acceptance
(n = 12) at 7 mo, normal kidney function and histology with no further treatment.
Transplant acceptance was associated with the influx of host stem cells,
resulting in a hybrid kidney and a modulated host immune response. Confirmation
of these results could initiate a paradigm shift in posttransplant therapy.