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10.1158/0008-5472.CAN-14-0923 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-0923 C4925010!4925010!25164016     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (21): 6330-40 Nephropedia Template TP {{tp|p=25164016|t=2014. Transient SNAIL1 Expression is Necessary for Metastatic Competence in Breast Cancer |pdf=|usr=}}{{25164016}} gab.com Text Transient SNAIL1 Expression is Necessary for Metastatic Competence in Breast Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25164016 #FOAvip SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of human breast tumor transcriptomes and experiments using cancer cell lines and xenografts. However, in vivo genetic experimental support for a role for SNAIL1 in breast cancer metastasis that develops in an immunocompetent tumor microenvironment has not been determined. To address this question, we created a genetic SNAIL1 model by coupling an endogenous SNAIL1 reporter with an inducible SNAIL1 transgene. Using multiple genetic models of breast cancer, we demonstrated that endogenous SNAIL1 expression was restricted to primary tumors that ultimately disseminate. SNAIL1 gene deletion either during the premalignant phase or after primary tumors have reached a palpable size blunted metastasis, indicating that late metastasis was the main driver of metastasis and that this was dependent on SNAIL1. Importantly, SNAIL1 expression during breast cancer metastasis was transient and forced transient, but not continuous, SNAIL1 expression in breast tumors was sufficient to increase metastasis. Twit Text FOAVip Transient SNAIL1 Expression is Necessary for Metastatic Competence in Breast Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25164016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25164016 #FOAvip English Wikipedia <ref>{{Cite pmid|25164016}}</ref> Transient SNAIL1 Expression is Necessary for Metastatic Competence in Breast Cancer #MMPMID25164016 Tran HD; Luitel K; Kim M; Zhang K; Longmore GD; Tran DD Cancer Res 2014[Nov]; 74 (21): 6330-40 PMID25164016show ga SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of human breast tumor transcriptomes and experiments using cancer cell lines and xenografts. However, in vivo genetic experimental support for a role for SNAIL1 in breast cancer metastasis that develops in an immunocompetent tumor microenvironment has not been determined. To address this question, we created a genetic SNAIL1 model by coupling an endogenous SNAIL1 reporter with an inducible SNAIL1 transgene. Using multiple genetic models of breast cancer, we demonstrated that endogenous SNAIL1 expression was restricted to primary tumors that ultimately disseminate. SNAIL1 gene deletion either during the premalignant phase or after primary tumors have reached a palpable size blunted metastasis, indicating that late metastasis was the main driver of metastasis and that this was dependent on SNAIL1. Importantly, SNAIL1 expression during breast cancer metastasis was transient and forced transient, but not continuous, SNAIL1 expression in breast tumors was sufficient to increase metastasis. äTransient SNAIL1 Expression is Necessary for Metastatic Competence in (epmc).pdf DeepDyve Pubget Overpricing