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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Annu+Rev+Pharmacol+Toxicol 2015 ; 55 (ä): 633-56 Nephropedia Template TP
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Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy #MMPMID25340931
Radonjic-Hoesli S; Valent P; Klion AD; Wechsler ME; Simon HU
Annu Rev Pharmacol Toxicol 2015[]; 55 (ä): 633-56 PMID25340931show ga
Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a life-long basis to keep eosinophil counts under control. In the last 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents, as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.