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10.1016/j.cell.2016.05.053

http://scihub22266oqcxt.onion/10.1016/j.cell.2016.05.053
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C4924582!4924582!27259145
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suck abstract from ncbi


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pmid27259145      Cell 2016 ; 165 (6): 1319-22
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  • Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine #MMPMID27259145
  • Popp MW; Maquat LE
  • Cell 2016[Jun]; 165 (6): 1319-22 PMID27259145show ga
  • Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.
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