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2016 ; 6
(ä): 29064
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Relationship between Functional and Structural Changes in Diabetic Vessels in
Optical Coherence Tomography Angiography
#MMPMID27350562
Miwa Y
; Murakami T
; Suzuma K
; Uji A
; Yoshitake S
; Fujimoto M
; Yoshitake T
; Tamura Y
; Yoshimura N
Sci Rep
2016[Jun]; 6
(ä): 29064
PMID27350562
show ga
The decorrelation signals in optical coherence tomography angiography (OCTA) are
derived from the flow of erythrocytes and concomitantly delineate the retinal
vasculature. We compared the structural and functional characteristics of
vascular lesions visualized in fluorescein angiography (FA), OCTA, and en-face
OCT images in 53 eyes (28 patients) with diabetic retinopathy (DR). The foveal
avascular zone (FAZ) areas in OCTA images in the superficial layer almost
corresponded to those in FA images. The FAZ areas in the en-face OCT images in
the superficial layer were smaller than those in the FA images and correlated
with each other, which agreed with the finding that en-face OCT images often
delineated the vascular structure in the nonperfused areas in FA images.
Microaneurysms appeared as fusiform, saccular, or coiled capillaries in OCTA
images and ringed, round, or oval hyperreflective lesions in en-face OCT images.
OCTA and en-face OCT images detected 41.0?±?16.1% and 40.1?±?18.6%, respectively,
of microaneurysms in FA images, although both depicted only 13.9?±?16.4%. The
number of microaneurysms in FA images was correlated with that in OCTA and
en-face OCT images. Comparisons of these modalities showed the associations and
dissociations between blood flow and vascular structures, which improves the
understanding of the pathogenesis of DR.