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10.1038/srep28897 http://scihub22266oqcxt.onion/10.1038/srep28897 C4924093!4924093 !27349231     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27349231 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases |pdf=|usr=}}{{27349231 }} gab.com Text Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27349231 #FOAvip Bone marrow mesenchymal stem cells (BMSCs) exhibit an increased propensity toward adipocyte differentiation accompanied by a reduction in osteogenesis in osteoporotic bone marrow. However, limited knowledge is available concerning the role of long non-coding RNAs (lncRNAs) in the differentiation of BMSCs into adipocytes. In this study, we demonstrated that lncRNA H19 and microRNA-675 (miR-675) derived from H19 were significantly downregulated in BMSCs that were differentiating into adipocytes. Overexpression of H19 and miR-675 inhibited adipogenesis, while knockdown of their endogenous expression accelerated adipogenic differentiation. Mechanistically, we found that miR-675 targeted the 3' untranslated regions of the histone deacetylase (HDAC) 4-6 transcripts and resulted in deregulation of HDACs 4-6, essential molecules in adipogenesis. In turn, trichostatin A, an HDAC inhibitor, significantly reduced CCCTC-binding factor (CTCF) occupancy in the imprinting control region upstream of the H19 gene locus and subsequently downregulated the expression of H19. These results show that the CTCF/H19/miR-675/HDAC regulatory pathway plays an important role in the commitment of BMSCs into adipocytes. Twit Text FOAVip Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27349231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27349231 #FOAvip English Wikipedia <ref>{{Cite pmid|27349231 }}</ref> Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases #MMPMID27349231 Huang Y ; Zheng Y ; Jin C ; Li X ; Jia L ; Li W Sci Rep 2016[Jun]; 6 (ä): 28897 PMID27349231 show ga Bone marrow mesenchymal stem cells (BMSCs) exhibit an increased propensity toward adipocyte differentiation accompanied by a reduction in osteogenesis in osteoporotic bone marrow. However, limited knowledge is available concerning the role of long non-coding RNAs (lncRNAs) in the differentiation of BMSCs into adipocytes. In this study, we demonstrated that lncRNA H19 and microRNA-675 (miR-675) derived from H19 were significantly downregulated in BMSCs that were differentiating into adipocytes. Overexpression of H19 and miR-675 inhibited adipogenesis, while knockdown of their endogenous expression accelerated adipogenic differentiation. Mechanistically, we found that miR-675 targeted the 3' untranslated regions of the histone deacetylase (HDAC) 4-6 transcripts and resulted in deregulation of HDACs 4-6, essential molecules in adipogenesis. In turn, trichostatin A, an HDAC inhibitor, significantly reduced CCCTC-binding factor (CTCF) occupancy in the imprinting control region upstream of the H19 gene locus and subsequently downregulated the expression of H19. These results show that the CTCF/H19/miR-675/HDAC regulatory pathway plays an important role in the commitment of BMSCs into adipocytes. |Adipocytes/cytology/*metabolism [MESH] |Adipogenesis/genetics [MESH] |Base Sequence [MESH] |Bone Marrow Cells/cytology/metabolism [MESH] |Cell Differentiation/*genetics [MESH] |Cells, Cultured [MESH] |Epigenesis, Genetic [MESH] |Gene Expression [MESH] |HEK293 Cells [MESH] |Histone Deacetylases/*genetics/metabolism [MESH] |Humans [MESH] |Mesenchymal Stem Cells/cytology/*metabolism [MESH] |MicroRNAs/*genetics [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/*genetics [MESH]Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Mar(epmc).pdf DeepDyve Pubget Overpricing