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10.1038/srep28914 http://scihub22266oqcxt.onion/10.1038/srep28914 C4923948!4923948!27349479     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27349479|t=2016. RIG-I inhibits pancreatic ? cell proliferation through competitive binding of activated Src |pdf=|usr=}}{{27349479}} gab.com Text RIG-I inhibits pancreatic cell proliferation through competitive binding of activated Src JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27349479 #FOAvip Nutrition is a necessary condition for cell proliferation, including pancreatic ? cells; however, over-nutrition, and the resulting obesity and glucolipotoxicity, is a risk factor for the development of Type 2 diabetes mellitus (DM), and causes inhibition of pancreatic ?-cells proliferation and their loss of compensation for insulin resistance. Here, we showed that Retinoic acid (RA)-inducible gene I (RIG-I) responds to nutrient signals and induces loss of ? cell mass through G1 cell cycle arrest. Risk factors for type 2 diabetes (e.g., glucolipotoxicity, TNF-? and LPS) activate Src in pancreatic ? cells. Elevated RIG-I modulated the interaction of activated Src and STAT3 by competitive binding to STAT3. Elevated RIG-I downregulated the transcription of SKP2, and increased the stability and abundance of P27 protein in a STAT3-dependent manner, which was associated with inhibition of ? cell growth elicited by Src. These results supported a role for RIG-I in ? cell mass loss under conditions of metabolic surplus and suggested that RIG-I-induced blocking of Src/STAT3 signalling might be involved in G1 phase cycle arrest through the Skp2/P27 pathway in pancreatic ? cells. Twit Text FOAVip RIG-I inhibits pancreatic cell proliferation through competitive binding of activated Src ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27349479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27349479 #FOAvip English Wikipedia <ref>{{Cite pmid|27349479}}</ref> RIG-I inhibits pancreatic ? cell proliferation through competitive binding of activated Src #MMPMID27349479 Pan Y; Li G; Zhong H; Chen M; Chen T; Gao L; Wu H; Guo J Sci Rep 2016[]; 6 (ä): ä PMID27349479show ga Nutrition is a necessary condition for cell proliferation, including pancreatic ? cells; however, over-nutrition, and the resulting obesity and glucolipotoxicity, is a risk factor for the development of Type 2 diabetes mellitus (DM), and causes inhibition of pancreatic ?-cells proliferation and their loss of compensation for insulin resistance. Here, we showed that Retinoic acid (RA)-inducible gene I (RIG-I) responds to nutrient signals and induces loss of ? cell mass through G1 cell cycle arrest. Risk factors for type 2 diabetes (e.g., glucolipotoxicity, TNF-? and LPS) activate Src in pancreatic ? cells. Elevated RIG-I modulated the interaction of activated Src and STAT3 by competitive binding to STAT3. Elevated RIG-I downregulated the transcription of SKP2, and increased the stability and abundance of P27 protein in a STAT3-dependent manner, which was associated with inhibition of ? cell growth elicited by Src. These results supported a role for RIG-I in ? cell mass loss under conditions of metabolic surplus and suggested that RIG-I-induced blocking of Src/STAT3 signalling might be involved in G1 phase cycle arrest through the Skp2/P27 pathway in pancreatic ? cells. äRIG-I inhibits pancreatic ? cell proliferation through competitive bin(epmc).pdf DeepDyve Pubget Overpricing