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10.3233/JAD-150236 http://scihub22266oqcxt.onion/10.3233/JAD-150236 C4923756!4923756 !26401929     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26401929 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Alzheimers+Dis 2015 ; 48 (1 ): 63-72 Nephropedia Template TP {{tp|p=26401929 |t=2015. Increased Number of Plasma B Cells Producing Autoantibodies Against A?42 Protofibrils in Alzheimer s Disease |pdf=|usr=}}{{26401929 }} gab.com Text Increased Number of Plasma B Cells Producing Autoantibodies Against A 42 Protofibrils in Alzheimer s Disease JO: J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=26401929 #FOAvip The Alzheimer's disease (AD)-related peptide amyloid-? (A?) has a propensity to aggregate into various assemblies including toxic soluble A? protofibrils. Several studies have reported the existence of anti-A? antibodies in humans. However, it is still debated whether levels of anti-A? antibodies are altered in AD patients compared to healthy individuals. Formation of immune complexes with plasma A? makes it difficult to reliably measure the concentration of circulating anti-A? antibodies with certain immunoassays, potentially leading to an underestimation. Here we have investigated anti-A? antibody production on a cellular level by measuring the amount of anti-A? antibody producing cells instead of the plasma level of anti-A? antibodies. To our knowledge, this is the first time the anti-A? antibody response in plasma has been compared in AD patients and age-matched healthy individuals using the enzyme-linked immunospot (ELISpot) technique. Both AD patients and healthy individuals had low levels of B cells producing antibodies binding A?40 monomers, whereas the number of cells producing antibodies toward A?42 protofibrils was higher overall and significantly higher in AD compared to healthy controls. This study shows, by an alternative and reliable method, that there is a specific immune response to the toxic A? protofibrils, which is significantly increased in AD patients. Twit Text FOAVip Increased Number of Plasma B Cells Producing Autoantibodies Against A 42 Protofibrils in Alzheimer s Disease ????J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=26401929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26401929 #FOAvip English Wikipedia <ref>{{Cite pmid|26401929 }}</ref> Increased Number of Plasma B Cells Producing Autoantibodies Against A?42 Protofibrils in Alzheimer s Disease #MMPMID26401929 Söllvander S ; Ekholm-Pettersson F ; Brundin RM ; Westman G ; Kilander L ; Paulie S ; Lannfelt L ; Sehlin D J Alzheimers Dis 2015[]; 48 (1 ): 63-72 PMID26401929 show ga The Alzheimer's disease (AD)-related peptide amyloid-? (A?) has a propensity to aggregate into various assemblies including toxic soluble A? protofibrils. Several studies have reported the existence of anti-A? antibodies in humans. However, it is still debated whether levels of anti-A? antibodies are altered in AD patients compared to healthy individuals. Formation of immune complexes with plasma A? makes it difficult to reliably measure the concentration of circulating anti-A? antibodies with certain immunoassays, potentially leading to an underestimation. Here we have investigated anti-A? antibody production on a cellular level by measuring the amount of anti-A? antibody producing cells instead of the plasma level of anti-A? antibodies. To our knowledge, this is the first time the anti-A? antibody response in plasma has been compared in AD patients and age-matched healthy individuals using the enzyme-linked immunospot (ELISpot) technique. Both AD patients and healthy individuals had low levels of B cells producing antibodies binding A?40 monomers, whereas the number of cells producing antibodies toward A?42 protofibrils was higher overall and significantly higher in AD compared to healthy controls. This study shows, by an alternative and reliable method, that there is a specific immune response to the toxic A? protofibrils, which is significantly increased in AD patients. |Aged [MESH] |Aged, 80 and over [MESH] |Alzheimer Disease/*blood/*immunology [MESH] |Amyloid beta-Peptides/*immunology/metabolism [MESH] |Autoantibodies/*metabolism [MESH] |B-Lymphocytes/*metabolism [MESH] |Biotinylation [MESH] |Case-Control Studies [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Male [MESH] |Mental Status Schedule [MESH]Increased Number of Plasma B Cells Producing Autoantibodies Against A?(epmc).pdf DeepDyve Pubget Overpricing