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2015 ; 12
(1-2
): 1-7
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Limits of computational biology
#MMPMID25318467
Bray D
In Silico Biol
2015[]; 12
(1-2
): 1-7
PMID25318467
show ga
Are we close to a complete inventory of living processes so that we might expect
in the near future to reproduce every essential aspect necessary for life? Or are
there mechanisms and processes in cells and organisms that are presently
inaccessible to us? Here I argue that a close examination of a particularly
well-understood system--that of Escherichia coli chemotaxis--shows we are still a
long way from a complete description. There is a level of molecular uncertainty,
particularly that responsible for fine-tuning and adaptation to myriad external
conditions, which we presently cannot resolve or reproduce on a computer.
Moreover, the same uncertainty exists for any process in any organism and is
especially pronounced and important in higher animals such as humans. Embryonic
development, tissue homeostasis, immune recognition, memory formation, and
survival in the real world, all depend on vast numbers of subtle variations in
cell chemistry most of which are presently unknown or only poorly characterized.
Overcoming these limitations will require us to not only accumulate large
quantities of highly detailed data but also develop new computational methods
able to recapitulate the massively parallel processing of living cells.
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