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Interplay of retinal determination gene network with TGF-? signaling pathway in
epithelial-mesenchymal transition
#MMPMID27358880
Liu Y
; Kong D
; Wu H
; Yuan X
; Xu H
; Zhang C
; Wu G
; Wu K
Stem Cell Investig
2015[]; 2
(?): 12
PMID27358880
show ga
As a fundamental event in the generation of tissues and organs during
embryogenesis, the epithelial-mesenchymal transition (EMT) has also been
implicated in cancer progression by its ability to alter the plasticity of
epithelial cells to acquire invasive properties. Evidence is mounting that
ectopic activation of transforming growth factors ? (TGF-?)/bone morphogenetic
protein (BMP) superfamily members to enhance tumorigenesis and metastasis. In
this respect, the Retinal Determination Gene Network (RDGN), which was identified
to govern the normal initiation of the morphogenetic furrow in Drosophila, has
now been found to be de-regulated in various types of cancers, and the key
members of this network, DACH, SIX, and EYA, have emerged as novel co-regulators
of TGF- signaling during EMT. Understanding the molecular mechanism by which RDGN
regulates TGF-?/BMP signaling to influence EMT may lead to novel strategies for
targeted therapies.
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