Animal models to achieve an HIV cure #MMPMID27152962
Kumar N; Chahroudi A; Silvestri G
Curr Opin HIV AIDS 2016[Jul]; 11 (4): 432-41 PMID27152962show ga
Purpose: The introduction of effective antiretroviral therapy (ART) has transformed HIV infection from a deadly to a chronic infection. Despite its successes in reducing mortality, ART fails to cure HIV allowing HIV persists in vivo. HIV persistence under ART is thought to be mediated by a combination of latent infection of long-lived cells, homeostatic proliferation of latently infected cells, anatomic sanctuaries and low-level virus replication. To understand the contribution of specific cell types and anatomic sites to virus persistence in vivo animal models are necessary. Recent findings: The advancements in ART and our understanding of animal models have facilitated the development of models of HIV persistence in nonhuman primates and mice. SIV or SHIV infection of rhesus and pigtail macaques followed by effective ART represents the most faithful animal model of HIV persistence. HIV infection of humanized mice also provides a useful model for answering specific questions regarding virus persistence in a uniquely mutable system. Summary: In this review we describe the most recent findings using animals models of HIV persistence. We will first describe the important aspects of HIV infection that SIV/SHIV infection of NHP are able to recapitulate, then we will discuss some recent studies that have used these models to understand viral persistence.
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Curr+Opin+HIV+AIDS 2016 ; 11 (4): 432-41
