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10.1038/srep28476 http://scihub22266oqcxt.onion/10.1038/srep28476 C4921916!4921916 !27346059     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27346059 &cmd=llinks): Failed to open stream: HTTP request failed! 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Amber Light (590?nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes |pdf=|usr=}}{{27346059 }} gab.com Text Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27346059 #FOAvip Lipolysis in the adipocytes provides free fatty acids for other tissues in response to the energy demand. With the rapid increase in obesity-related diseases, finding novel stimuli or mechanisms that regulate lipid metabolism becomes important. We examined the effects of visible light (410, 457, 505, 530, 590, and 660?nm) irradiation on lipolysis regulation in adipocytes differentiated from human adipose-derived stem cells (ADSCs). Interestingly, 590?nm (amber) light irradiation significantly reduced the concentration of lipid droplets (LDs). We further investigated the lipolytic signaling pathways that are involved in 590?nm light irradiation-induced breakdown of LDs. Immunoblot analysis revealed that 590?nm light irradiation-induced phosphorylation of hormone-sensitive lipase (HSL) was insufficient to promote reduction of LDs. We observed that 590?nm light irradiation decreased the expression of perilipin 1. We found that 590?nm light irradiation, but not 505?nm, induced conversion of LC3 I to LC3 II, a representative autophagic marker. We further demonstrated that the lysosomal inhibitors leupeptin/NH4Cl inhibited 590?nm light irradiation-induced reduction of LDs in differentiated adipocytes. Our data suggest that 590?nm light irradiation-induced LD breakdown is partially mediated by autophagy-related lysosomal degradation, and can be applied in clinical settings to reduce obesity. Twit Text FOAVip Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27346059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27346059 #FOAvip English Wikipedia <ref>{{Cite pmid|27346059 }}</ref> Amber Light (590?nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes #MMPMID27346059 Choi MS ; Kim HJ ; Ham M ; Choi DH ; Lee TR ; Shin DW Sci Rep 2016[Jun]; 6 (ä): 28476 PMID27346059 show ga Lipolysis in the adipocytes provides free fatty acids for other tissues in response to the energy demand. With the rapid increase in obesity-related diseases, finding novel stimuli or mechanisms that regulate lipid metabolism becomes important. We examined the effects of visible light (410, 457, 505, 530, 590, and 660?nm) irradiation on lipolysis regulation in adipocytes differentiated from human adipose-derived stem cells (ADSCs). Interestingly, 590?nm (amber) light irradiation significantly reduced the concentration of lipid droplets (LDs). We further investigated the lipolytic signaling pathways that are involved in 590?nm light irradiation-induced breakdown of LDs. Immunoblot analysis revealed that 590?nm light irradiation-induced phosphorylation of hormone-sensitive lipase (HSL) was insufficient to promote reduction of LDs. We observed that 590?nm light irradiation decreased the expression of perilipin 1. We found that 590?nm light irradiation, but not 505?nm, induced conversion of LC3 I to LC3 II, a representative autophagic marker. We further demonstrated that the lysosomal inhibitors leupeptin/NH4Cl inhibited 590?nm light irradiation-induced reduction of LDs in differentiated adipocytes. Our data suggest that 590?nm light irradiation-induced LD breakdown is partially mediated by autophagy-related lysosomal degradation, and can be applied in clinical settings to reduce obesity. |Adipocytes/metabolism/*physiology [MESH] |Amber [MESH] |Autophagy/*physiology [MESH] |Cell Differentiation/*physiology [MESH] |Cell Line [MESH] |Humans [MESH] |Lipase/metabolism [MESH] |Lipid Droplets/metabolism/*physiology [MESH] |Lipid Metabolism/physiology [MESH] |Lipolysis/physiology [MESH] |Lysosomes/*physiology [MESH] |Perilipin-1/metabolism [MESH] |Phosphorylation/physiology [MESH]Amber Light (590?nm) Induces the Breakdown of Lipid Droplets through (epmc).pdf DeepDyve Pubget Overpricing