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Mechanisms of cardiotoxicity of cancer chemotherapeutic agents: Cardiomyopathy and beyond #MMPMID27117975
Moudgil R; Yeh ET
Can J Cardiol 2016[Jul]; 32 (7): 863-870.e5 PMID27117975show ga
Tremendous strides have been made in the treatment of various oncological diseases such that patients are surviving longer and are having better quality of life. However, the success has been tainted by the iatrogenic cardiac toxicities. This is especially concerning in the younger population who are facing cardiac disease such as heart failure in their 30s and 40s as the consequence of the anthracycline?s side-effect (used for childhood leukemia and lymphoma). This resulted in the awareness of cardio-toxic effect of anticancer drugs and emergence of a new discipline: Onco-cardiology. Since then numerous anticancer drugs have been correlated to cardiomyopathy. Additionally, other cardiovascular effects have been identified which includes but no limited to the myocardial infarction, thrombosis, hypertension, arrhythmias and pulmonary hypertension. This review examines some of the anticancer agents mitigating cardiotoxicity and presents current knowledge of molecular mechanism(s). The aim of the review is to ignite awareness of emerging cardio-toxic effects as new generation of anticancer agents are being tested in clinical trials and introduced as part of therapeutic armamentarium to our oncological patients.