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10.1038/onc.2013.467 http://scihub22266oqcxt.onion/10.1038/onc.2013.467 C4921233!4921233 !24186204     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24186204 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2014 ; 33 (45 ): 5238-50 Nephropedia Template TP {{tp|p=24186204 |t=2014. Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells |pdf=|usr=}}{{24186204 }} gab.com Text Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=24186204 #FOAvip Metastatic breast tumors undergo epithelial-to-mesenchymal transition (EMT), which renders them resistant to therapies targeted to the primary cancers. The mechanistic link between mtDNA (mitochondrial DNA) reduction, often seen in breast cancer patients, and EMT is unknown. We demonstrate that reducing mtDNA content in human mammary epithelial cells (hMECs) activates Calcineurin (Cn)-dependent mitochondrial retrograde signaling pathway, which induces EMT-like reprogramming to fibroblastic morphology, loss of cell polarity, contact inhibition and acquired migratory and invasive phenotype. Notably, mtDNA reduction generates breast cancer stem cells. In addition to retrograde signaling markers, there is an induction of mesenchymal genes but loss of epithelial markers in these cells. The changes are reversed by either restoring the mtDNA content or knockdown of CnA? mRNA, indicating the causal role of retrograde signaling in EMT. Our results point to a new therapeutic strategy for metastatic breast cancers targeted to the mitochondrial retrograde signaling pathway for abrogating EMT and attenuating cancer stem cells, which evade conventional therapies. We report a novel regulatory mechanism by which low mtDNA content generates EMT and cancer stem cells in hMECs. Twit Text FOAVip Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=24186204 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24186204 #FOAvip English Wikipedia <ref>{{Cite pmid|24186204 }}</ref> Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells #MMPMID24186204 Guha M ; Srinivasan S ; Ruthel G ; Kashina AK ; Carstens RP ; Mendoza A ; Khanna C ; Van Winkle T ; Avadhani NG Oncogene 2014[Nov]; 33 (45 ): 5238-50 PMID24186204 show ga Metastatic breast tumors undergo epithelial-to-mesenchymal transition (EMT), which renders them resistant to therapies targeted to the primary cancers. The mechanistic link between mtDNA (mitochondrial DNA) reduction, often seen in breast cancer patients, and EMT is unknown. We demonstrate that reducing mtDNA content in human mammary epithelial cells (hMECs) activates Calcineurin (Cn)-dependent mitochondrial retrograde signaling pathway, which induces EMT-like reprogramming to fibroblastic morphology, loss of cell polarity, contact inhibition and acquired migratory and invasive phenotype. Notably, mtDNA reduction generates breast cancer stem cells. In addition to retrograde signaling markers, there is an induction of mesenchymal genes but loss of epithelial markers in these cells. The changes are reversed by either restoring the mtDNA content or knockdown of CnA? mRNA, indicating the causal role of retrograde signaling in EMT. Our results point to a new therapeutic strategy for metastatic breast cancers targeted to the mitochondrial retrograde signaling pathway for abrogating EMT and attenuating cancer stem cells, which evade conventional therapies. We report a novel regulatory mechanism by which low mtDNA content generates EMT and cancer stem cells in hMECs. |Animals [MESH] |Breast Neoplasms/*genetics/metabolism/pathology [MESH] |Calcineurin/genetics/metabolism [MESH] |Cell Line [MESH] |Cell Movement/genetics [MESH] |DNA, Mitochondrial/*genetics/metabolism [MESH] |DNA-Binding Proteins/genetics/metabolism [MESH] |Epithelial Cells/metabolism [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Female [MESH] |Gene Dosage [MESH] |Gene Expression [MESH] |Humans [MESH] |Immunoblotting [MESH] |Lung Neoplasms/genetics/metabolism/secondary [MESH] |MCF-7 Cells [MESH] |Mice, SCID [MESH] |Microscopy, Confocal [MESH] |Mitochondria/genetics/metabolism [MESH] |Mitochondrial Proteins/genetics/metabolism [MESH] |Neoplastic Stem Cells/*metabolism/pathology [MESH] |Oxygen Consumption/genetics [MESH] |RNA Interference [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction/*genetics [MESH] |Transcription Factors/genetics/metabolism [MESH]Mitochondrial retrograde signaling induces epithelial-mesenchymal tran(epmc).pdf DeepDyve Pubget Overpricing