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10.1016/j.cels.2016.04.015 http://scihub22266oqcxt.onion/10.1016/j.cels.2016.04.015 C4920955!4920955 !27237741     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27237741 &cmd=llinks): Failed to open stream: HTTP request failed! 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Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium |pdf=|usr=}}{{27237741 }} gab.com Text Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium JO: Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27237741 #FOAvip Coordination of transcription in bacteria occurs at supra-operonic scales, but the extent, specificity, and mechanisms of such regulation are poorly understood. Here, we tackle this problem by profiling the transcriptome of the model organism Mycoplasma pneumoniae across 115 growth conditions. We identify three qualitatively different levels of co-expression corresponding to distinct relative orientations and intergenic properties of adjacent genes. We reveal that the degree of co-expression between co-directional adjacent operons, and more generally between genes, is tightly related to their capacity to be transcribed en bloc into the same mRNA. We further show that this genome-wide pervasive transcription of adjacent genes and operons is specifically repressed by DNA regions preferentially bound by RNA polymerases, by intrinsic terminators, and by large intergenic distances. Taken together, our findings suggest that the basal coordination of transcription is mediated by the physical entities and mechanical properties of the transcription process itself, and that operon-like behaviors may strongly vary from condition to condition. Twit Text FOAVip Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium ????Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27237741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27237741 #FOAvip English Wikipedia <ref>{{Cite pmid|27237741 }}</ref> Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium #MMPMID27237741 Junier I ; Unal EB ; Yus E ; Lloréns-Rico V ; Serrano L Cell Syst 2016[Jun]; 2 (6 ): 391-401 PMID27237741 show ga Coordination of transcription in bacteria occurs at supra-operonic scales, but the extent, specificity, and mechanisms of such regulation are poorly understood. Here, we tackle this problem by profiling the transcriptome of the model organism Mycoplasma pneumoniae across 115 growth conditions. We identify three qualitatively different levels of co-expression corresponding to distinct relative orientations and intergenic properties of adjacent genes. We reveal that the degree of co-expression between co-directional adjacent operons, and more generally between genes, is tightly related to their capacity to be transcribed en bloc into the same mRNA. We further show that this genome-wide pervasive transcription of adjacent genes and operons is specifically repressed by DNA regions preferentially bound by RNA polymerases, by intrinsic terminators, and by large intergenic distances. Taken together, our findings suggest that the basal coordination of transcription is mediated by the physical entities and mechanical properties of the transcription process itself, and that operon-like behaviors may strongly vary from condition to condition. |*Genome, Bacterial [MESH] |Bacteria [MESH] |DNA-Directed RNA Polymerases [MESH] |Gene Expression Regulation, Bacterial [MESH] |Operon [MESH] |Promoter Regions, Genetic [MESH] |Transcription, Genetic [MESH]Insights into the Mechanisms of Basal Coordination of Transcription Us(epmc).pdf DeepDyve Pubget Overpricing