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10.1016/j.celrep.2016.05.054 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.05.054 C4920892!4920892!27292648     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (12): 2756-70 Nephropedia Template TP {{tp|p=27292648|t=2016. T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex |pdf=|usr=}}{{27292648}} gab.com Text T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27292648 #FOAvip The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super elongation complex (SEC). Th1 genes are occupied by H3K4me3 and RNA polymerase II in Th2 cells, while T-bet-mediated recruitment of P-TEFb in Th1 cells activates transcriptional elongation. P-TEFb is recruited to both genes and enhancers, where it activates enhancer RNA transcription. P-TEFb inhibition and Mediator and SEC knockdown selectively block activation of T-bet target genes, and P-TEFb inhibition abrogates Th1-associated experimental autoimmune uveitis. T-bet activity is independent of changes in NF-?B RelA and Brd4 binding, with T-bet- and NF-?B-mediated pathways instead converging to allow P-TEFb recruitment. These data provide insight into the mechanism through which lineage-specifying factors promote differentiation of alternative T cell fates. Twit Text FOAVip T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27292648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27292648 #FOAvip English Wikipedia <ref>{{Cite pmid|27292648}}</ref> T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex #MMPMID27292648 Hertweck A; Evans C; Eskandarpour M; Lau J; Oleinika K; Jackson I; Kelly A; Ambrose J; Adamson P; Cousins D; Lavender P; Calder V; Lord G; Jenner R Cell Rep 2016[Jun]; 15 (12): 2756-70 PMID27292648show ga The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super elongation complex (SEC). Th1 genes are occupied by H3K4me3 and RNA polymerase II in Th2 cells, while T-bet-mediated recruitment of P-TEFb in Th1 cells activates transcriptional elongation. P-TEFb is recruited to both genes and enhancers, where it activates enhancer RNA transcription. P-TEFb inhibition and Mediator and SEC knockdown selectively block activation of T-bet target genes, and P-TEFb inhibition abrogates Th1-associated experimental autoimmune uveitis. T-bet activity is independent of changes in NF-?B RelA and Brd4 binding, with T-bet- and NF-?B-mediated pathways instead converging to allow P-TEFb recruitment. These data provide insight into the mechanism through which lineage-specifying factors promote differentiation of alternative T cell fates. äT-bet Activates Th1 Genes through Mediator and the Super Elongation Co(epmc).pdf DeepDyve Pubget Overpricing