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10.1146/annurev-pharmtox-010715-103209 http://scihub22266oqcxt.onion/10.1146/annurev-pharmtox-010715-103209 C4919666!4919666!26738480     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Pharmacol+Toxicol 2016 ; 56 (ä): 605-26 Nephropedia Template TP {{tp|p=26738480|t=2016. Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?|pdf=|usr=}}{{26738480}} gab.com Text Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet JO: Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=26738480 #FOAvip Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in cell differentiation, development, proliferation, and metabolism and are associated with numerous liver pathologies such as cancer, steatosis, inflammation, fibrosis, cholestasis, and xenobiotic/drug-induced liver injury. The network of target proteins associated with NRs is extremely complex, comprising coregulators, small noncoding microRNAs, and long noncoding RNAs. The importance of NRs as targets of liver disease is exemplified by the number of NR ligands that are currently used in the clinics or in clinical trials with promising results. Understanding the regulation by NR during pathophysiological conditions, and identifying ligands for orphan NR, points to a potential therapeutic approach for patients with liver diseases. An overview of complex NR metabolic networks and their pharmacological implications in liver disease is presented here. Twit Text FOAVip Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet ????Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=26738480 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26738480 #FOAvip English Wikipedia <ref>{{Cite pmid|26738480}}</ref> Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet? #MMPMID26738480 Rudraiah S; Zhang X; Wang L Annu Rev Pharmacol Toxicol 2016[]; 56 (ä): 605-26 PMID26738480show ga Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in cell differentiation, development, proliferation, and metabolism and are associated with numerous liver pathologies such as cancer, steatosis, inflammation, fibrosis, cholestasis, and xenobiotic/drug-induced liver injury. The network of target proteins associated with NRs is extremely complex, comprising coregulators, small noncoding microRNAs, and long noncoding RNAs. The importance of NRs as targets of liver disease is exemplified by the number of NR ligands that are currently used in the clinics or in clinical trials with promising results. Understanding the regulation by NR during pathophysiological conditions, and identifying ligands for orphan NR, points to a potential therapeutic approach for patients with liver diseases. An overview of complex NR metabolic networks and their pharmacological implications in liver disease is presented here. äNuclear Receptors as Therapeutic Targets in Liver Disease: Are We Ther(epmc).pdf DeepDyve Pubget Overpricing