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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Pharmacol
2016 ; 173
(14
): 2165-81
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Obestatin as a key regulator of metabolism and cardiovascular function with
emerging therapeutic potential for diabetes
#MMPMID27111465
Cowan E
; Burch KJ
; Green BD
; Grieve DJ
Br J Pharmacol
2016[Jul]; 173
(14
): 2165-81
PMID27111465
show ga
Obestatin is a 23-amino acid C-terminally amidated gastrointestinal peptide
derived from preproghrelin and which forms an ? helix. Although obestatin has a
short biological half-life and is rapidly degraded, it is proposed to exert
wide-ranging pathophysiological actions. Whilst the precise nature of many of its
effects is unclear, accumulating evidence supports positive actions on both
metabolism and cardiovascular function. For example, obestatin has been reported
to inhibit food and water intake, body weight gain and gastrointestinal motility
and also to mediate promotion of cell survival and prevention of apoptosis.
Obestatin-induced increases in beta cell mass, enhanced adipogenesis and improved
lipid metabolism have been noted along with up-regulation of genes associated
with beta cell regeneration, insulin production and adipogenesis. Furthermore,
human circulating obestatin levels generally demonstrate an inverse association
with obesity and diabetes, whilst the peptide has been shown to confer protective
metabolic effects in experimental diabetes, suggesting that it may hold
therapeutic potential in this setting. Obestatin also appears to be involved in
blood pressure regulation and to exert beneficial effects on endothelial
function, with experimental studies indicating that it may also promote
cardioprotective actions against, for example, ischaemia-reperfusion injury. This
review will present a critical appraisal of the expanding obestatin research area
and discuss the emerging therapeutic potential of this peptide for both metabolic
and cardiovascular complications of diabetes.
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