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10.1111/bph.13509 http://scihub22266oqcxt.onion/10.1111/bph.13509 C4919580!4919580!27155948     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2016 ; 173 (14): 2195-207 Nephropedia Template TP {{tp|p=27155948|t=2016. GPCRdb: the G protein?coupled receptor database ? an introduction |pdf=|usr=}}{{27155948}} gab.com Text GPCRdb: the G protein coupled receptor database an introduction JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27155948 #FOAvip GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single?point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross?referenced by GPCRdb and web servers with corresponding functionality. Twit Text FOAVip GPCRdb: the G protein coupled receptor database an introduction ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27155948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27155948 #FOAvip English Wikipedia <ref>{{Cite pmid|27155948}}</ref> GPCRdb: the G protein?coupled receptor database ? an introduction #MMPMID27155948 Munk C; Isberg V; Mordalski S; Harpsøe K; Rataj K; Hauser AS; Kolb P; Bojarski AJ; Vriend G; Gloriam DE Br J Pharmacol 2016[Jul]; 173 (14): 2195-207 PMID27155948show ga GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single?point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross?referenced by GPCRdb and web servers with corresponding functionality. äGPCRdb: the G protein?coupled receptor database ? an introduction (epmc).pdf DeepDyve Pubget Overpricing