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10.1016/j.canlet.2015.12.019 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.12.019 C4919249!4919249 !26724680     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26724680 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Lett 2016 ; 380 (1 ): 330-9 Nephropedia Template TP {{tp|p=26724680 |t=2016. Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment |pdf=|usr=}}{{26724680 }} gab.com Text Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26724680 #FOAvip Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commonly used therapies either leverage a biological phenotype of cancer cells (e.g. high rate of proliferation) or indiscriminately kill all the cells present in a targeted volume. Tumor microenvironment (TME) targeting represents a promising therapeutic direction, because a number of TME hallmarks are conserved across different tumor types, despite the underlying genetic heterogeneity. Historically, TME targeting has largely focused on the cells that support tumor growth (e.g. vascular endothelial cells). However, by viewing the intrinsic physical and chemical alterations in the TME as additional therapeutic opportunities rather than barriers, a new class of TME-inspired treatments has great promise to complement or replace existing therapeutic strategies. In this review we summarize the physical and chemical hallmarks of the TME, and discuss how these tumor characteristics either currently are, or may ultimately be targeted to improve cancer therapies. Twit Text FOAVip Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26724680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26724680 #FOAvip English Wikipedia <ref>{{Cite pmid|26724680 }}</ref> Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment #MMPMID26724680 Ivey JW ; Bonakdar M ; Kanitkar A ; Davalos RV ; Verbridge SS Cancer Lett 2016[Sep]; 380 (1 ): 330-9 PMID26724680 show ga Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commonly used therapies either leverage a biological phenotype of cancer cells (e.g. high rate of proliferation) or indiscriminately kill all the cells present in a targeted volume. Tumor microenvironment (TME) targeting represents a promising therapeutic direction, because a number of TME hallmarks are conserved across different tumor types, despite the underlying genetic heterogeneity. Historically, TME targeting has largely focused on the cells that support tumor growth (e.g. vascular endothelial cells). However, by viewing the intrinsic physical and chemical alterations in the TME as additional therapeutic opportunities rather than barriers, a new class of TME-inspired treatments has great promise to complement or replace existing therapeutic strategies. In this review we summarize the physical and chemical hallmarks of the TME, and discuss how these tumor characteristics either currently are, or may ultimately be targeted to improve cancer therapies. |*Ablation Techniques/methods [MESH] |*Drug Delivery Systems/methods [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Antineoplastic Agents/*administration & dosage [MESH] |Drug Carriers [MESH] |Drug Resistance, Neoplasm [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Neoplasms/metabolism/pathology/*therapy [MESH]Improving cancer therapies by targeting the physical and chemical hall(epmc).pdf DeepDyve Pubget Overpricing