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10.1177/1073858415619600 http://scihub22266oqcxt.onion/10.1177/1073858415619600 C4919242!4919242!26700888     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroscientist 2017 ; 23 (1): 68-81 Nephropedia Template TP {{tp|p=26700888|t=2017. Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy |pdf=|usr=}}{{26700888}} gab.com Text Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy JO: Neuroscientist http://www.kidney.de/pget.php?&tw=1&pmid=26700888 #FOAvip The unpredictability and severity of seizures contribute to the debilitating nature of epilepsy. These factors also render the condition particularly challenging to treat, as an ideal treatment would need to detect and halt the pathological bursts of hyperactivity without disrupting normal brain activity. Optogenetic techniques offer promising tools to study and perhaps eventually treat this episodic disorder by controlling specific brain circuits in epileptic animals with great temporal precision. Here, we briefly review the current treatment options for patients with epilepsy. We then describe the many ways optogenetics has allowed us to untangle the microcircuits involved in seizure activity, and how it has, in some cases, changed our perception of previous theories of seizure generation. Control of seizures with light is no longer a dream, and has been achieved in numerous different animal models of epilepsy. Beyond its application as a seizure suppressor, we highlight another facet of optogenetics in epilepsy, namely the ability to create ?on-demand? seizures, as a tool to systematically probe the dynamics of networks during seizure initiation and propagation. Finally, we look into the future to discuss the possibilities and challenges of translating optogenetic techniques to clinical use. Twit Text FOAVip Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy ????Neuroscientist http://www.kidney.de/pget.php?&tw=1&pmid=26700888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26700888 #FOAvip English Wikipedia <ref>{{Cite pmid|26700888}}</ref> Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy #MMPMID26700888 Bui AD; Alexander A; Soltesz I Neuroscientist 2017[Feb]; 23 (1): 68-81 PMID26700888show ga The unpredictability and severity of seizures contribute to the debilitating nature of epilepsy. These factors also render the condition particularly challenging to treat, as an ideal treatment would need to detect and halt the pathological bursts of hyperactivity without disrupting normal brain activity. Optogenetic techniques offer promising tools to study and perhaps eventually treat this episodic disorder by controlling specific brain circuits in epileptic animals with great temporal precision. Here, we briefly review the current treatment options for patients with epilepsy. We then describe the many ways optogenetics has allowed us to untangle the microcircuits involved in seizure activity, and how it has, in some cases, changed our perception of previous theories of seizure generation. Control of seizures with light is no longer a dream, and has been achieved in numerous different animal models of epilepsy. Beyond its application as a seizure suppressor, we highlight another facet of optogenetics in epilepsy, namely the ability to create ?on-demand? seizures, as a tool to systematically probe the dynamics of networks during seizure initiation and propagation. Finally, we look into the future to discuss the possibilities and challenges of translating optogenetic techniques to clinical use. äSeizing Control: From Current Treatments to Optogenetic Interventions (epmc).pdf DeepDyve Pubget Overpricing