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10.1038/ni.3352 http://scihub22266oqcxt.onion/10.1038/ni.3352 C4919114!4919114!26829767     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (3): 286-96 Nephropedia Template TP {{tp|p=26829767|t=2016. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex |pdf=|usr=}}{{26829767}} gab.com Text SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26829767 #FOAvip SHARPIN forms a linear-ubiquitin-chain-assembly complex that promotes signaling via the transcription factor NF-?B. SHARPIN deficiency leads to progressive multi-organ inflammation and immune system malfunction, but how SHARPIN regulates T cell responses is unclear. Here we found that SHARPIN deficiency resulted in a substantial reduction in the number of and defective function of regulatory T cells (Treg cells). Transfer of SHARPIN-sufficient Treg cells into SHARPIN-deficient mice considerably alleviated their systemic inflammation. SHARPIN-deficient T cells displayed enhanced proximal signaling via the T cell antigen receptor (TCR) without an effect on the activation of NF-?B. SHARPIN conjugated with Lys63 (K63)-linked ubiquitin chains, which led to inhibition of the association of TCR? with the signaling kinase Zap70; this affected the generation of Treg cells. Our study therefore identifies a role for SHARPIN in TCR signaling whereby it maintains immunological homeostasis and tolerance by regulating Treg cells. Twit Text FOAVip SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26829767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26829767 #FOAvip English Wikipedia <ref>{{Cite pmid|26829767}}</ref> SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex #MMPMID26829767 Park Y; Jin Hs; Lopez J; Lee J; Liao L; Elly C; Liu YC Nat Immunol 2016[Mar]; 17 (3): 286-96 PMID26829767show ga SHARPIN forms a linear-ubiquitin-chain-assembly complex that promotes signaling via the transcription factor NF-?B. SHARPIN deficiency leads to progressive multi-organ inflammation and immune system malfunction, but how SHARPIN regulates T cell responses is unclear. Here we found that SHARPIN deficiency resulted in a substantial reduction in the number of and defective function of regulatory T cells (Treg cells). Transfer of SHARPIN-sufficient Treg cells into SHARPIN-deficient mice considerably alleviated their systemic inflammation. SHARPIN-deficient T cells displayed enhanced proximal signaling via the T cell antigen receptor (TCR) without an effect on the activation of NF-?B. SHARPIN conjugated with Lys63 (K63)-linked ubiquitin chains, which led to inhibition of the association of TCR? with the signaling kinase Zap70; this affected the generation of Treg cells. Our study therefore identifies a role for SHARPIN in TCR signaling whereby it maintains immunological homeostasis and tolerance by regulating Treg cells. äSHARPIN controls regulatory T cells by negatively modulating the T cel(epmc).pdf DeepDyve Pubget Overpricing