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10.1101/sqb.2015.80.027573 http://scihub22266oqcxt.onion/10.1101/sqb.2015.80.027573 C4918800!4918800 !26763983     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26763983 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Symp+Quant+Biol 2015 ; 80 (ä): 281-8 Nephropedia Template TP {{tp|p=26763983 |t=2015. Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks |pdf=|usr=}}{{26763983 }} gab.com Text Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks JO: Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=26763983 #FOAvip Transposable elements (TEs) may account for up to two-thirds of the human genome, and as genomic threats they are subjected to epigenetic control mechanisms engaged from the earliest stages of embryonic development. We previously determined that an important component of this process is the sequence-specific recognition of TEs by KRAB (Krüppel-associated box)-containing zinc-finger proteins (KRAB-ZFPs), a large family of tetrapod-restricted transcription factors that act by recruiting inducers of heterochromatin formation and DNA methylation. We further showed that KRAB-ZFPs and their cofactor KAP1 exert a marked influence on the transcription dynamics of embryonic stem cells via their docking of repressor complexes at TE-contained regulatory sequences. It is generally held that, beyond this early embryonic period, TEs become permanently silenced, and that the evolutionary selection of KRAB-ZFPs and other TE controllers is the result of a simple evolutionary arms race between the host and these genetics invaders. Here, I discuss recent evidence that invalidates this dual assumption and instead suggests that KRAB-ZFPs are the instruments of a massive enterprise of TE domestication, whereby transposon-based regulatory sequences and their cellular ligands establish species-specific transcription regulation networks that influence multiple aspects of human development and physiology. Twit Text FOAVip Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks ????Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=26763983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26763983 #FOAvip English Wikipedia <ref>{{Cite pmid|26763983 }}</ref> Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks #MMPMID26763983 Trono D Cold Spring Harb Symp Quant Biol 2015[]; 80 (ä): 281-8 PMID26763983 show ga Transposable elements (TEs) may account for up to two-thirds of the human genome, and as genomic threats they are subjected to epigenetic control mechanisms engaged from the earliest stages of embryonic development. We previously determined that an important component of this process is the sequence-specific recognition of TEs by KRAB (Krüppel-associated box)-containing zinc-finger proteins (KRAB-ZFPs), a large family of tetrapod-restricted transcription factors that act by recruiting inducers of heterochromatin formation and DNA methylation. We further showed that KRAB-ZFPs and their cofactor KAP1 exert a marked influence on the transcription dynamics of embryonic stem cells via their docking of repressor complexes at TE-contained regulatory sequences. It is generally held that, beyond this early embryonic period, TEs become permanently silenced, and that the evolutionary selection of KRAB-ZFPs and other TE controllers is the result of a simple evolutionary arms race between the host and these genetics invaders. Here, I discuss recent evidence that invalidates this dual assumption and instead suggests that KRAB-ZFPs are the instruments of a massive enterprise of TE domestication, whereby transposon-based regulatory sequences and their cellular ligands establish species-specific transcription regulation networks that influence multiple aspects of human development and physiology. |DNA Methylation/*genetics [MESH] |DNA Transposable Elements/*genetics [MESH] |Embryonic Stem Cells [MESH] |Epigenesis, Genetic [MESH] |Gene Expression Regulation, Developmental/*genetics [MESH] |Gene Regulatory Networks/*genetics [MESH] |Genome, Human [MESH] |Heterochromatin/metabolism [MESH] |Humans [MESH] |Kruppel-Like Transcription Factors/metabolism [MESH] |Transcription Factors/metabolism [MESH] |Tripartite Motif-Containing Protein 28/metabolism [MESH]Transposable Elements, Polydactyl Proteins, and the Genesis of Human-S(epmc).pdf DeepDyve Pubget Overpricing