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10.1038/srep28299 http://scihub22266oqcxt.onion/10.1038/srep28299 C4917863!4917863 !27333864     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27333864 &cmd=llinks): Failed to open stream: HTTP request failed! 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TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3 |pdf=|usr=}}{{27333864 }} gab.com Text TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27333864 #FOAvip Dysregulation of the Wnt pathway leading to accumulation of ?-catenin (CTNNB1) is a hallmark of colorectal cancer (CRC). Nuclear CTNNB1 acts as a transcriptional coactivator with TCF/LEF transcription factors, promoting expression of a broad set of target genes, some of which promote tumor growth. However, it remains poorly understood how CTNNB1 interacts with different transcription factors in different contexts to promote different outcomes. While some CTNNB1 target genes are oncogenic, others regulate differentiation. Here, we found that TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth. Loss of TCF7L1 impaired growth and colony formation of HCT116 CRC cells and reduced tumor growth in a mouse xenograft model. We identified a group of CTNNB1/TCF target genes that are activated in the absence of TCF7L1, including EPHB3, a marker of Paneth cell differentiation that has also been implicated as a tumor suppressor in CRC. Knockdown of EPHB3 partially restores growth and normal cell cycle progression of TCF7L1-Null cells. These findings suggest that while CTNNB1 accumulation is critical for CRC progression, activation of specific Wnt target genes in certain contexts may in fact inhibit tumor growth. Twit Text FOAVip TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27333864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27333864 #FOAvip English Wikipedia <ref>{{Cite pmid|27333864 }}</ref> TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3 #MMPMID27333864 Murphy M ; Chatterjee SS ; Jain S ; Katari M ; DasGupta R Sci Rep 2016[Jun]; 6 (ä): 28299 PMID27333864 show ga Dysregulation of the Wnt pathway leading to accumulation of ?-catenin (CTNNB1) is a hallmark of colorectal cancer (CRC). Nuclear CTNNB1 acts as a transcriptional coactivator with TCF/LEF transcription factors, promoting expression of a broad set of target genes, some of which promote tumor growth. However, it remains poorly understood how CTNNB1 interacts with different transcription factors in different contexts to promote different outcomes. While some CTNNB1 target genes are oncogenic, others regulate differentiation. Here, we found that TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth. Loss of TCF7L1 impaired growth and colony formation of HCT116 CRC cells and reduced tumor growth in a mouse xenograft model. We identified a group of CTNNB1/TCF target genes that are activated in the absence of TCF7L1, including EPHB3, a marker of Paneth cell differentiation that has also been implicated as a tumor suppressor in CRC. Knockdown of EPHB3 partially restores growth and normal cell cycle progression of TCF7L1-Null cells. These findings suggest that while CTNNB1 accumulation is critical for CRC progression, activation of specific Wnt target genes in certain contexts may in fact inhibit tumor growth. |Animals [MESH] |Colorectal Neoplasms/*metabolism/pathology [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HCT116 Cells [MESH] |Heterografts [MESH] |Humans [MESH] |Mice, Nude [MESH] |Receptor, EphB3/genetics/*metabolism [MESH] |TCF Transcription Factors/genetics/metabolism [MESH] |Transcription Factor 7-Like 1 Protein/genetics/*metabolism [MESH] |Wnt Signaling Pathway [MESH]TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of (epmc).pdf DeepDyve Pubget Overpricing