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10.1530/ERC-16-0059 http://scihub22266oqcxt.onion/10.1530/ERC-16-0059 C4917437!4917437!27207564     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Endocr+Relat+Cancer 2015 ; 23 (6): R229-47 Nephropedia Template TP {{tp|p=27207564|t=2015. Endocrine Neoplasms in Familial Syndromes of Hyperparathyroidism |pdf=|usr=}}{{27207564}} gab.com Text Endocrine Neoplasms in Familial Syndromes of Hyperparathyroidism JO: Endocr Relat Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27207564 #FOAvip Familial syndromes of hyperparathyroidism, including multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 2A (MEN2A), and the hyperparathyroidism-jaw tumor (HPT-JT), comprise 2 to 5% of primary hyperparathyroidism cases. Familial syndromes of hyperparathyroidism are also associated with a range of endocrine and non-endocrine tumors, including potential malignancies. Complications of the associated neoplasms are the major causes of morbidities and mortalities in these familial syndromes, e.g., parathyroid carcinoma in HPT-JT syndrome, thymic, bronchial and enteropancreatic neuroendocrine tumors in MEN1, and medullary thyroid cancer and pheochromocytoma in MEN2A. Because of the different underlying mechanisms of neoplasia, these familial tumors may have different characteristics compared to their sporadic counterparts. Large-scale clinical trials are frequently lacking due to the rarity of these diseases. With technological advances and the development of new medications, the natural history, diagnosis and management of these syndromes are also evolving. In this article, we summarize the recent knowledge on endocrine neoplasms in three familial hyperparathyroidism syndromes, with an emphasis on disease characteristics, molecular pathogenesis, recent developments in biochemical and radiological evaluation, and expert opinions on surgical and medical therapies. Because these familial hyperparathyroidism syndromes are associated with a wide variety of tumors in different organs, this review is focused on those endocrine neoplasms with malignant potential. Twit Text FOAVip Endocrine Neoplasms in Familial Syndromes of Hyperparathyroidism ????Endocr Relat Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27207564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27207564 #FOAvip English Wikipedia <ref>{{Cite pmid|27207564}}</ref> Endocrine Neoplasms in Familial Syndromes of Hyperparathyroidism #MMPMID27207564 Li Y; Simonds WF Endocr Relat Cancer 2015[Jun]; 23 (6): R229-47 PMID27207564show ga Familial syndromes of hyperparathyroidism, including multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 2A (MEN2A), and the hyperparathyroidism-jaw tumor (HPT-JT), comprise 2 to 5% of primary hyperparathyroidism cases. Familial syndromes of hyperparathyroidism are also associated with a range of endocrine and non-endocrine tumors, including potential malignancies. Complications of the associated neoplasms are the major causes of morbidities and mortalities in these familial syndromes, e.g., parathyroid carcinoma in HPT-JT syndrome, thymic, bronchial and enteropancreatic neuroendocrine tumors in MEN1, and medullary thyroid cancer and pheochromocytoma in MEN2A. Because of the different underlying mechanisms of neoplasia, these familial tumors may have different characteristics compared to their sporadic counterparts. Large-scale clinical trials are frequently lacking due to the rarity of these diseases. With technological advances and the development of new medications, the natural history, diagnosis and management of these syndromes are also evolving. In this article, we summarize the recent knowledge on endocrine neoplasms in three familial hyperparathyroidism syndromes, with an emphasis on disease characteristics, molecular pathogenesis, recent developments in biochemical and radiological evaluation, and expert opinions on surgical and medical therapies. Because these familial hyperparathyroidism syndromes are associated with a wide variety of tumors in different organs, this review is focused on those endocrine neoplasms with malignant potential. äEndocrine Neoplasms in Familial Syndromes of Hyperparathyroidism (epmc).pdf DeepDyve Pubget Overpricing