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10.1016/j.immuni.2016.04.013 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.04.013 C4917422!4917422!27261277     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2016 ; 44 (6): 1350-64 Nephropedia Template TP {{tp|p=27261277|t=2016. Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity |pdf=|usr=}}{{27261277}} gab.com Text Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27261277 #FOAvip T follicular helper (Tfh) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (Tfr) cells limit the GC reaction. Store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels mediated by STIM and ORAI proteins is a fundamental signaling pathway in T lymphocytes. Conditional deletion of Stim1 and Stim2 genes in T cells strongly reduced antibody-mediated immune responses following viral infection caused by impaired differentiation and function of Tfh cells. Conversely, aging Stim1Stim2-deficient mice developed humoral autoimmunity with spontaneous autoantibody production due to abolished Tfr cell differentiation in the presence of residual Tfh cells. Mechanistically, SOCE controlled Tfr and Tfh cell differentiation through NFAT-mediated IRF4, BATF and Bcl-6 transcription factor expression. SOCE had a dual role in controlling the GC reaction by regulating both Tfh and Tfr cell differentiation, thus enabling protective B cell responses and preventing humoral autoimmunity. Twit Text FOAVip Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27261277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27261277 #FOAvip English Wikipedia <ref>{{Cite pmid|27261277}}</ref> Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity #MMPMID27261277 Vaeth M; Eckstein M; Shaw P; Kozhaya L; Yang J; Berberich-Siebelt F; Clancy R; Unutmaz D; Feske S Immunity 2016[Jun]; 44 (6): 1350-64 PMID27261277show ga T follicular helper (Tfh) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (Tfr) cells limit the GC reaction. Store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels mediated by STIM and ORAI proteins is a fundamental signaling pathway in T lymphocytes. Conditional deletion of Stim1 and Stim2 genes in T cells strongly reduced antibody-mediated immune responses following viral infection caused by impaired differentiation and function of Tfh cells. Conversely, aging Stim1Stim2-deficient mice developed humoral autoimmunity with spontaneous autoantibody production due to abolished Tfr cell differentiation in the presence of residual Tfh cells. Mechanistically, SOCE controlled Tfr and Tfh cell differentiation through NFAT-mediated IRF4, BATF and Bcl-6 transcription factor expression. SOCE had a dual role in controlling the GC reaction by regulating both Tfh and Tfr cell differentiation, thus enabling protective B cell responses and preventing humoral autoimmunity. äStore-operated Ca2+ entry in follicular T cells controls humoral immun(epmc).pdf DeepDyve Pubget Overpricing