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10.1038/ni.3433 http://scihub22266oqcxt.onion/10.1038/ni.3433 C4917298!4917298!27043414     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (5): 514-22 Nephropedia Template TP {{tp|p=27043414|t=2016. S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3 |pdf=|usr=}}{{27043414}} gab.com Text S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27043414 #FOAvip Cytosolic DNA-mediated activation of the transcription factor IRF3 is a key event in host antiviral responses. Here, we show that infection of DNA viruses induced the interaction of the mTOR downstream effector S6K1 (S6 kinase 1) and the signaling adaptor STING in a cGAS (cGAMP synthase)-dependent manner. We further demonstrate that the kinase domain, but not the kinase function of S6K1, was required for the S6K1-STING interaction and that the TBK1 critically promotes this process. The formation of a tripartite S6K1-STING-TBK1 complex was necessary for IRF3 activation and disruption of this signaling axis impaired the early-phase expression of IRF3 target genes and the induction of T cell responses and mucosal antiviral immunity. Thus, our results have uncovered a fundamental regulatory mechanism for IRF3 activation in the cytosolic DNA pathway. Twit Text FOAVip S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27043414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27043414 #FOAvip English Wikipedia <ref>{{Cite pmid|27043414}}</ref> S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3 #MMPMID27043414 Wang F; Alain T; Szretter KJ; Stephenson K; Pol JG; Atherton MJ; Hoang HD; Fonseca BD; Zakaria C; Chen L; Rangwala Z; Hesch A; Chan ESY; Tuinman C; Suthar MS; Jiang Z; Ashkar AA; Thomas G; Kozma SC; Gale M; Fitzgerald KA; Diamond MS; Mossman K; Sonenberg N; Wan Y; Lichty BD Nat Immunol 2016[May]; 17 (5): 514-22 PMID27043414show ga Cytosolic DNA-mediated activation of the transcription factor IRF3 is a key event in host antiviral responses. Here, we show that infection of DNA viruses induced the interaction of the mTOR downstream effector S6K1 (S6 kinase 1) and the signaling adaptor STING in a cGAS (cGAMP synthase)-dependent manner. We further demonstrate that the kinase domain, but not the kinase function of S6K1, was required for the S6K1-STING interaction and that the TBK1 critically promotes this process. The formation of a tripartite S6K1-STING-TBK1 complex was necessary for IRF3 activation and disruption of this signaling axis impaired the early-phase expression of IRF3 target genes and the induction of T cell responses and mucosal antiviral immunity. Thus, our results have uncovered a fundamental regulatory mechanism for IRF3 activation in the cytosolic DNA pathway. äS6K-STING interaction regulates cytosolic DNA-mediated activation of t(epmc).pdf DeepDyve Pubget Overpricing