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10.1016/j.it.2016.01.002 http://scihub22266oqcxt.onion/10.1016/j.it.2016.01.002 C4916957!4916957!26839260     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2016 ; 37 (3): 193-207 Nephropedia Template TP {{tp|p=26839260|t=2016. IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance |pdf=|usr=}}{{26839260}} gab.com Text IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26839260 #FOAvip Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell activation, either spontaneous or due to immunotherapy. Here we review the current understanding of mechanisms by which IDO participates in the control of inflammation and in peripheral tolerance. Focusing on the tumor microenvironment, we examine the role of IDO in response to apoptotic cells and the impact of IDO on Treg cell function. We discuss how the counter-regulatory and tolerogenic functions of IDO can be targeted for cancer immunotherapy and present an overview of the current clinical progress in this area. Twit Text FOAVip IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26839260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26839260 #FOAvip English Wikipedia <ref>{{Cite pmid|26839260}}</ref> IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance #MMPMID26839260 Munn DH; Mellor AL Trends Immunol 2016[Mar]; 37 (3): 193-207 PMID26839260show ga Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell activation, either spontaneous or due to immunotherapy. Here we review the current understanding of mechanisms by which IDO participates in the control of inflammation and in peripheral tolerance. Focusing on the tumor microenvironment, we examine the role of IDO in response to apoptotic cells and the impact of IDO on Treg cell function. We discuss how the counter-regulatory and tolerogenic functions of IDO can be targeted for cancer immunotherapy and present an overview of the current clinical progress in this area. äIDO in the Tumor Microenvironment: Inflammation, Counter-regulation an(epmc).pdf DeepDyve Pubget Overpricing