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10.1038/ni.3462 http://scihub22266oqcxt.onion/10.1038/ni.3462 C4916016!4916016 !27213689     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27213689 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol |pdf=|usr=}}{{27213689 }} gab.com Text Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27213689 #FOAvip Most adaptive immune responses require the activation of specific T cells through the T cell antigen receptor (TCR)-CD3 complex. Here we show that cholesterol sulfate (CS), a naturally occurring analog of cholesterol, inhibits CD3 ITAM phosphorylation, a crucial first step in T cell activation. In biochemical studies, CS disrupted TCR multimers, apparently by displacing cholesterol, which is known to bind TCR?. Moreover, CS-deficient mice showed heightened sensitivity to a self-antigen, whereas increasing CS content by intrathymic injection inhibited thymic selection, indicating that this molecule is an intrinsic regulator of thymocyte development. These results reveal a regulatory role for CS in TCR signaling and thymic selection, highlighting the importance of the membrane microenvironment in modulating cell surface receptor activation. Twit Text FOAVip Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27213689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27213689 #FOAvip English Wikipedia <ref>{{Cite pmid|27213689 }}</ref> Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol #MMPMID27213689 Wang F ; Beck-García K ; Zorzin C ; Schamel WW ; Davis MM Nat Immunol 2016[Jul]; 17 (7 ): 844-50 PMID27213689 show ga Most adaptive immune responses require the activation of specific T cells through the T cell antigen receptor (TCR)-CD3 complex. Here we show that cholesterol sulfate (CS), a naturally occurring analog of cholesterol, inhibits CD3 ITAM phosphorylation, a crucial first step in T cell activation. In biochemical studies, CS disrupted TCR multimers, apparently by displacing cholesterol, which is known to bind TCR?. Moreover, CS-deficient mice showed heightened sensitivity to a self-antigen, whereas increasing CS content by intrathymic injection inhibited thymic selection, indicating that this molecule is an intrinsic regulator of thymocyte development. These results reveal a regulatory role for CS in TCR signaling and thymic selection, highlighting the importance of the membrane microenvironment in modulating cell surface receptor activation. |Animals [MESH] |Autoimmunity/genetics [MESH] |Cell Membrane/*metabolism [MESH] |Cells, Cultured [MESH] |Cholesterol Esters/*metabolism [MESH] |Cholesterol/analogs & derivatives/*metabolism [MESH] |Clonal Selection, Antigen-Mediated [MESH] |Lymphocyte Activation [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Phosphorylation [MESH] |Protein Multimerization/genetics [MESH] |Receptors, Antigen, T-Cell, alpha-beta/metabolism [MESH] |Signal Transduction [MESH] |Sulfotransferases/genetics [MESH] |T-Lymphocytes/*physiology [MESH]Inhibition of T cell receptor signaling by cholesterol sulfate, a natu(epmc).pdf DeepDyve Pubget Overpricing