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10.1038/ni.3463 http://scihub22266oqcxt.onion/10.1038/ni.3463 C4915981!4915981 !27135603     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27135603 &cmd=llinks): Failed to open stream: HTTP request failed! 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A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 |pdf=|usr=}}{{27135603 }} gab.com Text A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27135603 #FOAvip Signaling via the inducible costimulator ICOS fuels the stepwise development of follicular helper T cells (TFH cells). However, a signaling pathway unique to ICOS has not been identified. We found here that the kinase TBK1 associated with ICOS via a conserved motif, IProx, that shares homology with the tumor-necrosis-factor receptor (TNFR)-associated factors TRAF2 and TRAF3. Disruption of this motif abolished the association of TBK1 with ICOS, TRAF2 and TRAF3, which identified a TBK1-binding consensus. Alteration of this motif in ICOS or depletion of TBK1 in T cells severely impaired the differentiation of germinal center (GC) TFH cells and the development of GCs, interfered with B cell differentiation and disrupted the development of antibody responses, but the IProx motif and TBK1 were dispensable for the early differentiation of TFH cells. These results reveal a previously unknown ICOS-TBK1 signaling pathway that specifies the commitment of GC TFH cells. Twit Text FOAVip A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27135603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27135603 #FOAvip English Wikipedia <ref>{{Cite pmid|27135603 }}</ref> A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 #MMPMID27135603 Pedros C ; Zhang Y ; Hu JK ; Choi YS ; Canonigo-Balancio AJ ; Yates JR 3rd ; Altman A ; Crotty S ; Kong KF Nat Immunol 2016[Jul]; 17 (7 ): 825-33 PMID27135603 show ga Signaling via the inducible costimulator ICOS fuels the stepwise development of follicular helper T cells (TFH cells). However, a signaling pathway unique to ICOS has not been identified. We found here that the kinase TBK1 associated with ICOS via a conserved motif, IProx, that shares homology with the tumor-necrosis-factor receptor (TNFR)-associated factors TRAF2 and TRAF3. Disruption of this motif abolished the association of TBK1 with ICOS, TRAF2 and TRAF3, which identified a TBK1-binding consensus. Alteration of this motif in ICOS or depletion of TBK1 in T cells severely impaired the differentiation of germinal center (GC) TFH cells and the development of GCs, interfered with B cell differentiation and disrupted the development of antibody responses, but the IProx motif and TBK1 were dispensable for the early differentiation of TFH cells. These results reveal a previously unknown ICOS-TBK1 signaling pathway that specifies the commitment of GC TFH cells. |Animals [MESH] |Antibody Formation/genetics [MESH] |B-Lymphocytes/*physiology [MESH] |CD4-Positive T-Lymphocytes/*physiology [MESH] |Cell Differentiation/genetics [MESH] |Cells, Cultured [MESH] |Germinal Center/*immunology [MESH] |Inducible T-Cell Co-Stimulator Protein/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |Signal Transduction [MESH] |TNF Receptor-Associated Factor 2/genetics [MESH]A TRAF-like motif of the inducible costimulator ICOS controls developm(epmc).pdf DeepDyve Pubget Overpricing