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10.1093/biostatistics/kxw004 http://scihub22266oqcxt.onion/10.1093/biostatistics/kxw004 C4915611!4915611!26873961     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biostatistics 2016 ; 17 (3): 523-36 Nephropedia Template TP {{tp|p=26873961|t=2016. Inference for the existence of hormetic dose?response relationships in toxicology studies |pdf=|usr=}}{{26873961}} gab.com Text Inference for the existence of hormetic dose response relationships in toxicology studies JO: Biostatistics http://www.kidney.de/pget.php?&tw=1&pmid=26873961 #FOAvip In toxicology studies hormesis refers to a dose?response relationship with a stimulatory response at low doses and an inhibitory response at high doses. In this manuscript, we particularly focus on a J-shaped dose?response relationship for binary cancer responses. We propose and examine two new flexible models for testing the hypothesis of hormesis in a Bayesian framework. The first model is parametric and enhances the flexibility of modeling a hormetic zone by using a non-linear predictor in a multistage model. The second model is non-parametric and allows multiple model specifications, weighting the contribution of each model via Bayesian model averaging (BMA). Simulation studies show that the non-parametric modeling approach with BMA provides robust sensitivity and specificity for detecting hormesis relative to the parametric approach, regardless of the shape of a hormetic zone. Twit Text FOAVip Inference for the existence of hormetic dose response relationships in toxicology studies ????Biostatistics http://www.kidney.de/pget.php?&tw=1&pmid=26873961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26873961 #FOAvip English Wikipedia <ref>{{Cite pmid|26873961}}</ref> Inference for the existence of hormetic dose?response relationships in toxicology studies #MMPMID26873961 Kim SB; Bartell SM; Gillen DL Biostatistics 2016[Jul]; 17 (3): 523-36 PMID26873961show ga In toxicology studies hormesis refers to a dose?response relationship with a stimulatory response at low doses and an inhibitory response at high doses. In this manuscript, we particularly focus on a J-shaped dose?response relationship for binary cancer responses. We propose and examine two new flexible models for testing the hypothesis of hormesis in a Bayesian framework. The first model is parametric and enhances the flexibility of modeling a hormetic zone by using a non-linear predictor in a multistage model. The second model is non-parametric and allows multiple model specifications, weighting the contribution of each model via Bayesian model averaging (BMA). Simulation studies show that the non-parametric modeling approach with BMA provides robust sensitivity and specificity for detecting hormesis relative to the parametric approach, regardless of the shape of a hormetic zone. äInference for the existence of hormetic dose?response relationships in(epmc).pdf DeepDyve Pubget Overpricing