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10.1016/j.coph.2016.01.005 http://scihub22266oqcxt.onion/10.1016/j.coph.2016.01.005 C4915478!4915478!26874237     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Pharmacol 2016 ; 27 (ä): 31-7 Nephropedia Template TP {{tp|p=26874237|t=2016. Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response |pdf=|usr=}}{{26874237}} gab.com Text Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response JO: Curr Opin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26874237 #FOAvip Thiazide (TZD) diuretics are among the most commonly prescribed antihypertensives globally; however their chronic blood pressure (BP) lowering mechanism remains unclear. Herein we discuss the current evidence regarding specific mechanisms regulating the antihypertensive effects of TZDs, suggesting that TZDs act via multiple complex and interacting mechanisms, including natriuresis with short term use and direct vasodilatory effects chronically. Additionally, we review pharmacogenomics signals that have been associated with TZDs BP-response in several cohorts (i.e. NEDD4L, PRKCA, EDNRA-GNAS, and YEATS4) and discuss how these genes might be related to TZD BP-response mechanism.Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response. Twit Text FOAVip Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response ????Curr Opin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26874237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26874237 #FOAvip English Wikipedia <ref>{{Cite pmid|26874237}}</ref> Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response #MMPMID26874237 Shahin MH; Johnson JA Curr Opin Pharmacol 2016[Apr]; 27 (ä): 31-7 PMID26874237show ga Thiazide (TZD) diuretics are among the most commonly prescribed antihypertensives globally; however their chronic blood pressure (BP) lowering mechanism remains unclear. Herein we discuss the current evidence regarding specific mechanisms regulating the antihypertensive effects of TZDs, suggesting that TZDs act via multiple complex and interacting mechanisms, including natriuresis with short term use and direct vasodilatory effects chronically. Additionally, we review pharmacogenomics signals that have been associated with TZDs BP-response in several cohorts (i.e. NEDD4L, PRKCA, EDNRA-GNAS, and YEATS4) and discuss how these genes might be related to TZD BP-response mechanism.Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response. äMechanisms and pharmacogenetic signals underlying thiazide diuretics b(epmc).pdf DeepDyve Pubget Overpricing