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10.1016/j.cell.2016.05.046 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.05.046 C4915377!4915377!27259150     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (6): 1416-27 Nephropedia Template TP {{tp|p=27259150|t=2016. Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression |pdf=|usr=}}{{27259150}} gab.com Text Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27259150 #FOAvip Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association studies, we implicate tRNAGluUUC and tRNAArgCCG as promoters of breast cancer metastasis. Upregulation of these tRNAs enhances stability and ribosome occupancy of transcripts enriched for their cognate codons. Specifically, tRNAGluUUC promotes metastatic progression by directly enhancing EXOSC2 expression and enhancing GRIPAP1?constituting an ?inducible? pathway driven by a tRNA. The cellular proteomic shift toward a prometastatic state mirrors global tRNA shifts, allowing for cell-state and cell-type transgene expression optimization through codon content quantification. TRNA modulation represents a mechanism by which cells achieve altered expression of specific transcripts and proteins. TRNAs are thus dynamic regulators of gene expression and the tRNA codon landscape can causally and specifically impact disease progression. Twit Text FOAVip Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27259150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27259150 #FOAvip English Wikipedia <ref>{{Cite pmid|27259150}}</ref> Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression #MMPMID27259150 Goodarzi H; Nguyen HC; Zhang S; Dill BD; Molina H; Tavazoie SF Cell 2016[Jun]; 165 (6): 1416-27 PMID27259150show ga Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association studies, we implicate tRNAGluUUC and tRNAArgCCG as promoters of breast cancer metastasis. Upregulation of these tRNAs enhances stability and ribosome occupancy of transcripts enriched for their cognate codons. Specifically, tRNAGluUUC promotes metastatic progression by directly enhancing EXOSC2 expression and enhancing GRIPAP1?constituting an ?inducible? pathway driven by a tRNA. The cellular proteomic shift toward a prometastatic state mirrors global tRNA shifts, allowing for cell-state and cell-type transgene expression optimization through codon content quantification. TRNA modulation represents a mechanism by which cells achieve altered expression of specific transcripts and proteins. TRNAs are thus dynamic regulators of gene expression and the tRNA codon landscape can causally and specifically impact disease progression. äModulated Expression of Specific tRNAs Drives Gene Expression and Canc(epmc).pdf DeepDyve Pubget Overpricing