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10.1002/ana.24656 http://scihub22266oqcxt.onion/10.1002/ana.24656 C4914895!4914895!27044000     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Neurol 2016 ; 79 (6): 983-90 Nephropedia Template TP {{tp|p=27044000|t=2016. DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases |pdf=|usr=}}{{27044000}} gab.com Text DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27044000 #FOAvip Objective: The polyglutamine diseases, including Huntington's disease (HD) and multiple spinocerebellar ataxias (SCAs), are among the commonest hereditary neurodegenerative diseases. They are caused by expanded CAG tracts, encoding glutamine, in different genes. Longer CAG repeat tracts are associated with earlier ages at onset, but this does not account for all of the difference, and the existence of additional genetic modifying factors has been suggested in these diseases. A recent genome?wide association study (GWAS) in HD found association between age at onset and genetic variants in DNA repair pathways, and we therefore tested whether the modifying effects of variants in DNA repair genes have wider effects in the polyglutamine diseases. Methods: We assembled an independent cohort of 1,462 subjects with HD and polyglutamine SCAs, and genotyped single?nucleotide polymorphisms (SNPs) selected from the most significant hits in the HD study. Results: In the analysis of DNA repair genes as a group, we found the most significant association with age at onset when grouping all polyglutamine diseases (HD+SCAs; p = 1.43 × 10?5). In individual SNP analysis, we found significant associations for rs3512 in FAN1 with HD+SCAs (p = 1.52 × 10?5) and all SCAs (p = 2.22 × 10?4) and rs1805323 in PMS2 with HD+SCAs (p = 3.14 × 10?5), all in the same direction as in the HD GWAS. Interpretation: We show that DNA repair genes significantly modify age at onset in HD and SCAs, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats that can be modulated by genetic manipulation of DNA repair in disease models. This offers novel therapeutic opportunities in multiple diseases. Ann Neurol 2016;79:983?990 Twit Text FOAVip DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27044000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27044000 #FOAvip English Wikipedia <ref>{{Cite pmid|27044000}}</ref> DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases #MMPMID27044000 Bettencourt C; Hensman?Moss D; Flower M; Wiethoff S; Brice A; Goizet C; Stevanin G; Koutsis G; Karadima G; Panas M; Yescas?Gómez P; García?Velázquez LE; Alonso?Vilatela ME; Lima M; Raposo M; Traynor B; Sweeney M; Wood N; Giunti P; Durr A; Holmans P; Houlden H; Tabrizi SJ; Jones L Ann Neurol 2016[Jun]; 79 (6): 983-90 PMID27044000show ga Objective: The polyglutamine diseases, including Huntington's disease (HD) and multiple spinocerebellar ataxias (SCAs), are among the commonest hereditary neurodegenerative diseases. They are caused by expanded CAG tracts, encoding glutamine, in different genes. Longer CAG repeat tracts are associated with earlier ages at onset, but this does not account for all of the difference, and the existence of additional genetic modifying factors has been suggested in these diseases. A recent genome?wide association study (GWAS) in HD found association between age at onset and genetic variants in DNA repair pathways, and we therefore tested whether the modifying effects of variants in DNA repair genes have wider effects in the polyglutamine diseases. Methods: We assembled an independent cohort of 1,462 subjects with HD and polyglutamine SCAs, and genotyped single?nucleotide polymorphisms (SNPs) selected from the most significant hits in the HD study. Results: In the analysis of DNA repair genes as a group, we found the most significant association with age at onset when grouping all polyglutamine diseases (HD+SCAs; p = 1.43 × 10?5). In individual SNP analysis, we found significant associations for rs3512 in FAN1 with HD+SCAs (p = 1.52 × 10?5) and all SCAs (p = 2.22 × 10?4) and rs1805323 in PMS2 with HD+SCAs (p = 3.14 × 10?5), all in the same direction as in the HD GWAS. Interpretation: We show that DNA repair genes significantly modify age at onset in HD and SCAs, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats that can be modulated by genetic manipulation of DNA repair in disease models. This offers novel therapeutic opportunities in multiple diseases. Ann Neurol 2016;79:983?990 äDNA repair pathways underlie a common genetic mechanism modulating ons(epmc).pdf DeepDyve Pubget Overpricing