Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep28065 http://scihub22266oqcxt.onion/10.1038/srep28065 C4914849!4914849 !27325182     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27325182 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 28065 Nephropedia Template TP {{tp|p=27325182 |t=2016. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells |pdf=|usr=}}{{27325182 }} gab.com Text High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27325182 #FOAvip Follicular helper T cells (Tfh) have been well documented to play a critical role in autoimmunity, such as systemic lupus erythematosus (SLE), by helping B cells. In this study, high salt (sodium chloride, NaCl), under physiological conditions, was demonstrated to increase the differentiation of Tfh. A high-salt diet markedly increased lupus features in MRL/lpr mice. The mechanism is NaCl-induced DNA demethylation via the recruitment of the hydroxytransferase Ten-Eleven Translocation 2 (TET2). Gene silencing of TET2 obviously diminished NaCl-induced Tfh cell polarization in vitro. In addition, the gene expression of sh2d1a, map3k1, spn and stat5b was enhanced after NaCl treatment, consistent with the findings in lupus CD4(+)T cells. However, only spn was directly regulated by TET2, and spn was not the sole target for NaCl. Our findings not only explain the epigenetic mechanisms of high-salt induced autoimmunity but also provide an attractive molecular target for intervention strategies of patients. Twit Text FOAVip High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27325182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27325182 #FOAvip English Wikipedia <ref>{{Cite pmid|27325182 }}</ref> High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells #MMPMID27325182 Wu H ; Huang X ; Qiu H ; Zhao M ; Liao W ; Yuan S ; Xie Y ; Dai Y ; Chang C ; Yoshimura A ; Lu Q Sci Rep 2016[Jun]; 6 (ä): 28065 PMID27325182 show ga Follicular helper T cells (Tfh) have been well documented to play a critical role in autoimmunity, such as systemic lupus erythematosus (SLE), by helping B cells. In this study, high salt (sodium chloride, NaCl), under physiological conditions, was demonstrated to increase the differentiation of Tfh. A high-salt diet markedly increased lupus features in MRL/lpr mice. The mechanism is NaCl-induced DNA demethylation via the recruitment of the hydroxytransferase Ten-Eleven Translocation 2 (TET2). Gene silencing of TET2 obviously diminished NaCl-induced Tfh cell polarization in vitro. In addition, the gene expression of sh2d1a, map3k1, spn and stat5b was enhanced after NaCl treatment, consistent with the findings in lupus CD4(+)T cells. However, only spn was directly regulated by TET2, and spn was not the sole target for NaCl. Our findings not only explain the epigenetic mechanisms of high-salt induced autoimmunity but also provide an attractive molecular target for intervention strategies of patients. |Animals [MESH] |Autoimmunity/*drug effects [MESH] |CD4-Positive T-Lymphocytes/cytology/drug effects/metabolism [MESH] |Cell Differentiation/*drug effects [MESH] |Cell Polarity/drug effects [MESH] |Cells, Cultured [MESH] |DNA Demethylation/*drug effects [MESH] |DNA-Binding Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Dioxygenases [MESH] |Leukocytes, Mononuclear/cytology [MESH] |Lupus Erythematosus, Systemic/metabolism/mortality/pathology [MESH] |MAP Kinase Kinase Kinase 1/genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred MRL lpr [MESH] |Proto-Oncogene Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |RNA Interference [MESH] |STAT5 Transcription Factor/genetics/metabolism [MESH] |Sodium Chloride, Dietary/*pharmacology [MESH] |Survival Rate [MESH]High salt promotes autoimmunity by TET2-induced DNA demethylation and (epmc).pdf DeepDyve Pubget Overpricing