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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Genet+Dev 2016 ; 37 (ä): 76-81 Nephropedia Template TP
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Pioneer Transcription Factors, Chromatin Dynamics, and Cell Fate Control #MMPMID26826681
Zaret KS; Mango S
Curr Opin Genet Dev 2016[Apr]; 37 (ä): 76-81 PMID26826681show ga
Among the diverse transcription factors that are necessary to elicit changes in cell fate, both in embryonic development and in cellular reprogramming, a subset of factors are capable of binding to their target sequences on nucleosomal DNA and initiating regulatory events in silent chromatin. Such ?pioneer transcription factors? initiate cooperative interactions with other regulatory proteins to elicit changes in local chromatin structure. As a consequence of pioneer factor binding, the local chromatin can either become open and competent for activation, closed and repressed, or transcriptionally active. Understanding how pioneer factors initiate chromatin dynamics and how such can be blocked at heterochromatic sites provides insights into controlling cell fate transitions at will.