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10.1016/j.gde.2015.11.008 http://scihub22266oqcxt.onion/10.1016/j.gde.2015.11.008 C4914405!4914405!26845042     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Genet+Dev 2016 ; 37 (ä): 67-75 Nephropedia Template TP {{tp|p=26845042|t=2016. Replication origins: determinants or consequences of nuclear organization?|pdf=|usr=}}{{26845042}} gab.com Text Replication origins: determinants or consequences of nuclear organization JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=26845042 #FOAvip Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and is affected by transcriptional activity. Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency. The flexibility observed in the replication initiation landscape might help achieve complete and accurate genome duplication while coordinating the DNA replication program with transcription and other nuclear processes in a cell-type specific manner. This review discusses the relationships among replication origin distribution, local and global chromatin structures and concomitant nuclear metabolic processes. Twit Text FOAVip Replication origins: determinants or consequences of nuclear organization ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=26845042 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26845042 #FOAvip English Wikipedia <ref>{{Cite pmid|26845042}}</ref> Replication origins: determinants or consequences of nuclear organization? #MMPMID26845042 Marks AB; Smith OK; Aladjem MI Curr Opin Genet Dev 2016[Apr]; 37 (ä): 67-75 PMID26845042show ga Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and is affected by transcriptional activity. Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency. The flexibility observed in the replication initiation landscape might help achieve complete and accurate genome duplication while coordinating the DNA replication program with transcription and other nuclear processes in a cell-type specific manner. This review discusses the relationships among replication origin distribution, local and global chromatin structures and concomitant nuclear metabolic processes. äReplication origins: determinants or consequences of nuclear organizat(epmc).pdf DeepDyve Pubget Overpricing