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10.1016/j.celrep.2016.04.034 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.034 C4914391!4914391 !27160903     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27160903 &cmd=llinks): Failed to open stream: HTTP request failed! 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Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer |pdf=|usr=}}{{27160903 }} gab.com Text Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27160903 #FOAvip 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increased survival and proliferation of cancer cells in vitro and in vivo. miR551b-3p upregulates STAT3 protein levels, and STAT3 is required for the effects of miR551b-3p on cell proliferation. Rather than decreasing levels of target mRNA as expected, we demonstrate that miR551b-3p binds a complementary sequence on the STAT3 promoter, recruiting RNA polymerase II and the TWIST1 transcription factor to activate STAT3 transcription, and thus directly upregulates STAT3 expression. Furthermore, anti-miR551b reduced STAT3 expression in ovarian cancer cells in vitro and in vivo and reduced ovarian cancer growth in vivo. Together, our data demonstrate a role for miR551b-3p in transcriptional activation. Thus, miR551b-3p represents a promising candidate biomarker and therapeutic target in ovarian cancer. Twit Text FOAVip Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27160903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27160903 #FOAvip English Wikipedia <ref>{{Cite pmid|27160903 }}</ref> Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer #MMPMID27160903 Chaluvally-Raghavan P ; Jeong KJ ; Pradeep S ; Silva AM ; Yu S ; Liu W ; Moss T ; Rodriguez-Aguayo C ; Zhang D ; Ram P ; Liu J ; Lu Y ; Lopez-Berestein G ; Calin GA ; Sood AK ; Mills GB Cell Rep 2016[May]; 15 (7 ): 1493-1504 PMID27160903 show ga 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increased survival and proliferation of cancer cells in vitro and in vivo. miR551b-3p upregulates STAT3 protein levels, and STAT3 is required for the effects of miR551b-3p on cell proliferation. Rather than decreasing levels of target mRNA as expected, we demonstrate that miR551b-3p binds a complementary sequence on the STAT3 promoter, recruiting RNA polymerase II and the TWIST1 transcription factor to activate STAT3 transcription, and thus directly upregulates STAT3 expression. Furthermore, anti-miR551b reduced STAT3 expression in ovarian cancer cells in vitro and in vivo and reduced ovarian cancer growth in vivo. Together, our data demonstrate a role for miR551b-3p in transcriptional activation. Thus, miR551b-3p represents a promising candidate biomarker and therapeutic target in ovarian cancer. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Carcinoma, Ovarian Epithelial [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Cell Self Renewal [MESH] |Cell Survival/genetics [MESH] |Down-Regulation/genetics [MESH] |Female [MESH] |Gene Amplification [MESH] |Gene Knockdown Techniques [MESH] |Gene Silencing [MESH] |Humans [MESH] |Mice, Nude [MESH] |MicroRNAs/*metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasms, Glandular and Epithelial/*genetics/*pathology [MESH] |Nuclear Proteins/metabolism [MESH] |Ovarian Neoplasms/*genetics/*pathology [MESH] |Promoter Regions, Genetic/genetics [MESH] |RNA Polymerase II/metabolism [MESH] |STAT3 Transcription Factor/*genetics/metabolism [MESH] |Spheroids, Cellular/metabolism/pathology [MESH] |Transcription, Genetic [MESH] |Treatment Outcome [MESH] |Tumor Burden/genetics [MESH] |Twist-Related Protein 1/metabolism [MESH]Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth an(epmc).pdf DeepDyve Pubget Overpricing