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10.7554/eLife.14864 http://scihub22266oqcxt.onion/10.7554/eLife.14864 C4914367!4914367!27192037     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27192037|t=2016. Compaction and segregation of sister chromatids via active loop extrusion |pdf=|usr=}}{{27192037}} gab.com Text Compaction and segregation of sister chromatids via active loop extrusion JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27192037 #FOAvip The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle chromosomes, arriving at individualized chromatids with morphology observed in vivo. Our model resolves the paradox of topological simplification concomitant with chromosome 'condensation', and explains how enzymes a few nanometers in size are able to control chromosome geometry and topology at micron length scales. We suggest that loop extrusion is a universal mechanism of genome folding that mediates functional interactions during interphase and compacts chromosomes during mitosis.DOI:http://dx.doi.org/10.7554/eLife.14864.001 Twit Text FOAVip Compaction and segregation of sister chromatids via active loop extrusion ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27192037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27192037 #FOAvip English Wikipedia <ref>{{Cite pmid|27192037}}</ref> Compaction and segregation of sister chromatids via active loop extrusion #MMPMID27192037 Goloborodko A; Imakaev MV; Marko JF; Mirny L eLife 2016[]; 5 (ä): ä PMID27192037show ga The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle chromosomes, arriving at individualized chromatids with morphology observed in vivo. Our model resolves the paradox of topological simplification concomitant with chromosome 'condensation', and explains how enzymes a few nanometers in size are able to control chromosome geometry and topology at micron length scales. We suggest that loop extrusion is a universal mechanism of genome folding that mediates functional interactions during interphase and compacts chromosomes during mitosis.DOI:http://dx.doi.org/10.7554/eLife.14864.001 äCompaction and segregation of sister chromatids via active loop extrus(epmc).pdf DeepDyve Pubget Overpricing